The AT-rich interaction domain (ARID) family of DNA-binding proteins is a group of
transcription factors and chromatin regulators with a highly conserved ARID domain that …

Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However,
we are currently unaware of any studies using selective and potent ClpP activators in lung …

Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential
for adeno-to-squamous transdifferentiation (AST). However, it remains largely unknown how …

Phenotypic plasticity is a rising cancer hallmark, and lung adeno-to-squamous transition
(AST) triggered by LKB1 inactivation is significantly associated with drug resistance …

Background Cryoablation is a minimally invasive option for patients with medically
inoperable non-small cell lung cancer (NSCLC) and can trigger abscopal immune …

Background Metabolic-associated fatty liver disease (MAFLD) is a major cause of liver
disease worldwide and comprises non-alcoholic fatty liver (NAFL) and non-alcoholic …

The high mortality in men with metastatic prostate cancer (PC) establishes the need for
diagnostic optimization by new biomarkers. Mindful of the effect of real microgravity on …

Background Colorectal cancer (CRC) is a prevalent malignancy with diverse molecular
characteristics. The NGS-based approach enhances our comprehension of genomic …

Background: Colorectal cancer (CRC) is a heterogeneous disease with many somatic
mutations defining its genomic instability. Alternative Splicing (AS) events, are essential for …

背景与目的: 结直肠癌(colorectal carcinoma, CRC) 是一种常见的恶性肿瘤,
其发病率和死亡率仅次于胃癌和食管癌, 在消化系统恶性肿瘤中居第二位. 越来越多的证据表明 …