Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity

CM Hebner, LA Laimins - Reviews in medical virology, 2006 - Wiley Online Library
Human papillomaviruses (HPVs) are small double‐stranded DNA viruses that infect the
cutaneous and mucosal epithelium. Infection by specific HPV types has been linked to the …

Human papillomavirus infection: biology, epidemiology, and prevention

ME SCHEURER, G Tortolero-Luna… - International Journal of …, 2005 - ijgc.bmj.com
Over the past several decades, knowledge of the biology and epidemiology of human
papillomavirus (HPV) infection has increased tremendously. However, there are still many …

[HTML][HTML] The E4 protein; structure, function and patterns of expression

J Doorbar - Virology, 2013 - Elsevier
The papillomavirus E4 open reading frame (ORF) is contained within the E2 ORF, with the
primary E4 gene-product (E1∧ E4) being translated from a spliced mRNA that includes the …

Differential Immunogenicity of Epstein-Barr Virus Latent-Cycle Proteins for Human CD4+ T-Helper 1 Responses

ANN Leen, P Meij, I Redchenko, J Middeldorp… - Journal of …, 2001 - Am Soc Microbiol
ABSTRACT Human CD4+ T-helper 1 cell responses to Epstein-Barr virus (EBV) infection
are likely to be important in the maintenance of virus-specific CD8+ memory and/or as …

Characterization of events during the late stages of HPV16 infectionin vivousing high-affinity synthetic fabs to E4

J Doorbar, C Foo, N Coleman, L Medcalf, O Hartley… - Virology, 1997 - Elsevier
HPV late gene expression is initiated as an infected basal cell migrates through the
differentiating layers of the epidermis, resulting in the onset of vegetative viral DNA …

A risk for non-sexual transmission of human papillomavirus?

EJ Ryndock, C Meyers - Expert review of anti-infective therapy, 2014 - Taylor & Francis
Human papillomaviruses (HPVs) are estimated to be the most common sexually transmitted
virus in humans. The virus is of great interest as it is the etiological agent of cervical cancer …

Functional Analysis of the Human Papillomavirus Type 16 E1E4 Protein Provides a Mechanism for In Vivo and In Vitro Keratin Filament Reorganization

Q Wang, H Griffin, S Southern, D Jackson… - Journal of …, 2004 - Am Soc Microbiol
High-risk human papillomaviruses, such as human papillomavirus type 16 (HPV16), are the
primary cause of cervical cancer. The HPV16 E1∧ E4 protein associates with keratin …

Identification of a G2 Arrest Domain in the E1∧E4 Protein of Human Papillomavirus Type 16

CE Davy, DJ Jackson, Q Wang, K Raj… - Journal of …, 2002 - Am Soc Microbiol
ABSTRACT Human papillomavirus type 16 (HPV16) is the most common cause of cervical
carcinoma. Cervical cancer develops from low-grade lesions that support the productive …

Human Papillomavirus Type 16 E1E4 Contributes to Multiple Facets of the Papillomavirus Life Cycle

T Nakahara, WL Peh, J Doorbar, D Lee… - Journal of …, 2005 - Am Soc Microbiol
The life cycle of human papillomaviruses (HPVs) is tightly linked to the differentiation
program of the host's stratified epithelia that it infects. E1∧ E4 is a viral protein that has been …

Transient expression of epidermal filaggrin in cultured cells causes collapse of intermediate filament networks with alteration of cell shape and nuclear integrity.

BA Dale, RB Presland, SP Lewis… - Journal of investigative …, 1997 - Elsevier
Filaggrin is an intermediate filament-associated protein (IFAP) that aggregates epidermal
keratin filaments in vitro and is thought to perform a similar function during terminal …