Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)

JI Aguirre, EJ Castillo, DB Kimmel - Bone, 2021 - Elsevier
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event
affecting patients with cancer and patients with osteoporosis who have been treated with …

Mitigating osteonecrosis of the jaw (ONJ) through preventive dental care and understanding of risk factors

JT Wan, DM Sheeley, MJ Somerman, JS Lee - Bone research, 2020 - nature.com
It is well established that alterations in phosphate metabolism have a profound effect on
hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the …

Biologic and pathologic aspects of osteocytes in the setting of medication-related osteonecrosis of the jaw (MRONJ)

JI Aguirre, EJ Castillo, DB Kimmel - Bone, 2021 - Elsevier
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe, debilitating
condition affecting patients with cancer and patients with osteoporosis who have been …

Medication‐related osteonecrosis of the jaw: a literature review and update

S Kuroshima, FA Al‐Omari, M Sasaki, T Sawase - Genesis, 2022 - Wiley Online Library
Since the initial description of medication‐related osteonecrosis of the jaw (MRONJ) almost
two decades ago, the potential pathophysiology and risk factors have been elaborated on in …

Dose-Dependent Effects of Zoledronic Acid on Human Periodontal Ligament Stem Cells: An In Vitro Pilot Study

A Di Vito, E Chiarella, F Baudi… - Cell …, 2020 - journals.sagepub.com
Bisphosphonates (BPs) are widely used to treat several metabolic and oncological diseases
affecting the skeletal system. Despite BPs' well-known therapeutic potential, they also …

The role of the immune response in the development of medication-related osteonecrosis of the jaw

W Zhang, L Gao, W Ren, S Li, J Zheng, S Li… - Frontiers in …, 2021 - frontiersin.org
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse drug
effect. There are multiple hypotheses to explain the development of MRONJ. Reduced bone …

Denosumab and zoledronic acid differently affect circulating immune subsets: A possible role in the onset of MRONJ

I Roato, L Pavone, R Pedraza, I Bosso, G Baima… - Cells, 2023 - mdpi.com
This work investigated whether the anti-resorptive drugs (ARDs) zoledronic acid (Zol) and
denosumab (Dmab) affect differently the levels of circulating immune cell subsets, possibly …

Pathophysiology of Medication‐Related Osteonecrosis of the Jaw—A Minireview

S Tetradis, MR Allen, SL Ruggiero - Journal of Bone and Mineral …, 2023 - academic.oup.com
Medication‐related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse effect of
antiresorptive medications administered for control of osseous malignancy, osteoporosis, or …

The preventive effect of photocrosslinked Hep/GelMA hydrogel loaded with PRF on MRONJ

L Tao, Y Gao, Y Li, L Yang, J Yao, H Huang, J Yu… - BMC Oral Health, 2024 - Springer
Background Medication-related osteonecrosis of the Jaw (MRONJ) is a rare but severe side
effect in patients treated with medications such as Bisphosphonates (BPs). Its …

Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw (MRONJ)

R Yan, R Jiang, L Hu, Y Deng, J Wen… - International journal of …, 2022 - nature.com
Medication-related osteonecrosis of the jaw (MRONJ) is primarily associated with
administering antiresorptive or antiangiogenic drugs. Despite significant research on …