Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell
death response. Resistance to cell death is linked to cellular transformation and …

Caspase-2 was discovered almost three decades ago. It was one of the first two mammalian
homologs of CED-3, the other being interleukin 1β-converting enzyme (ICE/caspase-1) …

Metabolism in cells adapts quickly to changes in nutrient availability and cellular
differentiation status, including growth conditions in cell culture settings. The last decade …

Centrosomes are membrane-less organelles that orchestrate a wide array of biological
functions by acting as microtubule organizing centers. Here, we report that caspase-2 …

Caspase-2 belongs to the caspase family of proteins responsible for essential cellular
functions including apoptosis and inflammation. Uniquely, caspase-2 has been identified as …

Cell death is a major mechanism to eliminate cells in which DNA is damaged, organelles
are stressed, or oncogenes are overexpressed, all events that would otherwise predispose …

Genomic instability underlies genesis and the development of various types of cancer.
During tumorigenesis, cancer initiating cells assume a set of features, which allow them to …

Deregulated centrosome numbers are frequently found in human cancer and can promote
malignancies in model organisms. Current research aims to clarify if extra centrosomes are …

The PIDDosome is often used as the alias for a multi-protein complex that includes the p53-
induced death domain protein 1 (PIDD1), the bipartite linker protein CRADD (also known as …

SUMOylation regulates numerous cellular stress responses, yet targets in the apoptotic
machinery remain elusive. We show that a single, DNA damage-induced monoSUMOylation …