The role of neuromodulation in the management of drug-resistant epilepsy

HE Salama, A Salama, L Oscher, GI Jallo… - Neurological …, 2024 - Springer
Drug-resistant epilepsy (DRE) poses significant challenges in terms of effective
management and seizure control. Neuromodulation techniques have emerged as promising …

Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice

P Kleis, E Paschen, A Djie-Maletz, A Vlachos, CA Haas… - bioRxiv, 2025 - biorxiv.org
Background: Mesial temporal lobe epilepsy (MTLE) is a prevalent form of focal epilepsy
characterized by seizures originating from the hippocampus and adjacent regions …

Closed-loop Low-frequency stimulation: seizure reduction and more

JH Goodman - Epilepsy Currents, 2024 - journals.sagepub.com
Effect of the Closed-Loop Hippocampal Low-Frequency Stimulation on Seizure Severity,
Learning, and Memory in Pilocarpine Epilepsy Rat Model Zare M, Rezaei M, Nazari M …

Photopharmacological activation of adenosine A1 receptor signaling suppresses seizures in a mouse model for temporal lobe epilepsy

J Spanoghe, P Boon, M Vergaelen, M De Colvenaer… - bioRxiv, 2024 - biorxiv.org
Up to 30% of epilepsy patients suffer from drug-resistant epilepsy (DRE). The search for
innovative therapies is therefore important to close the existing treatment gap in these …