[HTML][HTML] MicroRNAs: target recognition and regulatory functions

DP Bartel - cell, 2009 - cell.com
MicroRNAs (miRNAs) are endogenous∼ 23 nt RNAs that play important gene-regulatory
roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their …

Desperately seeking microRNA targets

M Thomas, J Lieberman, A Lal - Nature structural & molecular biology, 2010 - nature.com
MicroRNAs (miRNAs) suppress gene expression by inhibiting translation, promoting mRNA
decay or both. Each miRNA may regulate hundreds of genes to control the cell's response to …

[HTML][HTML] Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

Y Tay, L Kats, L Salmena, D Weiss, SM Tan, U Ala… - Cell, 2011 - cell.com
Here, we demonstrate that protein-coding RNA transcripts can crosstalk by competing for
common microRNAs, with microRNA response elements as the foundation of this …

Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs

DM Garcia, D Baek, C Shin, GW Bell… - Nature structural & …, 2011 - nature.com
Most metazoan microRNAs (miRNAs) target many genes for repression, but the nematode
lsy-6 miRNA is much less proficient. Here we show that the low proficiency of lsy-6 can be …

Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

SW Chi, JB Zang, A Mele, RB Darnell - Nature, 2009 - nature.com
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as
miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA …

Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites

D Betel, A Koppal, P Agius, C Sander, C Leslie - Genome biology, 2010 - Springer
Abstract mirSVR is a new machine learning method for ranking microRNA target sites by a
down-regulation score. The algorithm trains a regression model on sequence and …

An alternative mode of microRNA target recognition

SW Chi, GJ Hannon, RB Darnell - Nature structural & molecular biology, 2012 - nature.com
MicroRNAs (miRNAs) regulate mRNA targets through perfect pairing with their seed region
(positions 2–7). Recently, a precise genome-wide map of miRNA interaction sites in mouse …

[HTML][HTML] Cell-type-based analysis of microRNA profiles in the mouse brain

M He, Y Liu, X Wang, MQ Zhang, GJ Hannon… - Neuron, 2012 - cell.com
MicroRNAs (miRNA) are implicated in brain development and function but the underlying
mechanisms have been difficult to study in part due to the cellular heterogeneity in neural …

Targeting of mRNAs by multiple miRNAs: the next step

ME Peter - Oncogene, 2010 - nature.com
Micro (mi) RNAs are small noncoding RNAs that regulate expression of the majority of the
genes in the genome at either the messenger RNA (mRNA) level (by degrading mRNA) or …

Target mRNA abundance dilutes microRNA and siRNA activity

A Arvey, E Larsson, C Sander, CS Leslie… - Molecular systems …, 2010 - embopress.org
Post‐transcriptional regulation by microRNAs and siRNAs depends not only on
characteristics of individual binding sites in target mRNA molecules, but also on system …