Abstract Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by
endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a …

Abstract Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly
relevant for physical and mental well-being; female and male health; in the modulation of …

Coronary artery disease remains a major cause of morbidity and mortality. Experimental and
clinical data have indicated an important role of endothelin-1 at various subclinical and …

The present study was undertaken to evaluate the cardio-protective potential of apricot-
feeding in the ischemia-reperfusion (I/R) model of rats in vivo. Rats were divided into three …

Purpose: This experimental study was designed to explore the protective effect of apocynin,
the NADPH-oxidase inhibitor, on kidney damage induced by ischemia/reperfusion (I/R) in a …

In the past 10 years, mortality from acute myocardial infarction has not decreased despite
the widespread introduction of percutaneous coronary intervention. The reason for this …

Patients with type two diabetes mellitus (T2DM) are at increased risk for cardiovascular
diseases. Impairments of endothelin-1 (ET-1) signaling and mTOR pathway have been …

Endothelin (ET) was first isolated and described by Yanagisawa et al. and has since been
described as one of the most potent known vasoconstrictor compounds. ET-1 mediates its …

Alzheimer's disease is a neurodegenerative disorder associated with abnormal
accumulation of amyloid-β (Aβ) which can release endothelin (ET). The present study was …

Oxidative stress, caused by the accumulation of reactive oxygen species (ROS) during acute
myocardial infarction (AMI), is one of the main factors leading to myocardial cell damage and …