Background Melatonin is widely available either on prescription for the treatment of sleep
disorders or as an over-the-counter dietary supplement. Melatonin has also recently been …

During the last 20 years, numerous clinical trials have examined the therapeutic usefulness
of melatonin in different fields of medicine. The objective of this article is to review, in depth …

While melatonin was once thought of simply as a sleep-inducing hormone, recent research
has resulted in development of a deeper understanding of the complex physiological activity …

Cardiovascular diseases account for approximately one‐third of all deaths each year. Of
this, hypertension accounts for approximately 9.4 million deaths. Melatonin, the primary …

The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

Background Patients with nocturnal hypertension are at higher risk for cardiovascular
complications such as myocardial infarction and cerebrovascular insult. Published studies …

Exogenous melatonin is commonly used for sleep disorders in older adults, and its use is
increasing over time. It appears to have modest efficacy in treating insomnia and circadian …

The role of the diet as well as the impact of the dietary habits on human health and disease
is well established. Apart from its sleep regulatory effect, the indoleamine melatonin is a well …

Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a
primary role in the initiation and perpetuation of hypertension, cardiovascular disease and …

Cardiovascular diseases (CVD) are among the leading causes of death worldwide. Many
lines of evidence suggest that the disturbances in circadian rhythm are responsible for the …