Microplastic particles (MP) are prevalent in both industrial production and the natural
environment, posing a significant concern for human health. Daily diet, air inhalation, and …

The maturation of human stem cell-derived cardiomyocytes (hSC-CMs) has been a major
challenge to further expand the scope of their application. Over the past years, several …

Microphysiological systems (MPS) are drawing increasing interest from academia and from
biomedical industry due to their improved capability to capture human physiology. MPS offer …

Mechanical forces impact cardiac cells and tissues over their entire lifespan, from
development to growth and eventually to pathophysiology. However, the mechanobiological …

The intermediate filament (IF) cytoskeleton supports cellular structural integrity, particularly
in response to mechanical stress. The most abundant IF proteins in mature cardiomyocytes …

Heart disease is one of the major life-threatening diseases with high mortality and incidence
worldwide. Several model systems, such as primary cells and animals, have been used to …

Atrioventricular block (AVB) is a severe disease for pediatric patients. The repetitive
operations needed in the case of the pacemaker implantation to maintain the electrical …

Cell alignment widely exists in various in vivo tissues and also plays an essential role in the
construction of in vitro models, such as vascular endothelial and myocardial models …

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) possess
tremendous potential for basic research and translational application. However, these cells …

Stem cell-based therapy has emerged as a promising approach for heart repair, potentially
regenerating damaged heart tissue and improving outcomes for patients with heart disease …