Hepatitis B virus cccDNA: Formation, regulation and therapeutic potential
Hepatitis B virus (HBV) infection remains a major public health concern worldwide with
about 257 million individuals chronically infected. Current therapies can effectively control …
about 257 million individuals chronically infected. Current therapies can effectively control …
Pathogenicity and virulence of Hepatitis B virus
Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are
an estimated 296 million people in the world that are chronically infected by this virus, and …
an estimated 296 million people in the world that are chronically infected by this virus, and …
Prospects for the global elimination of hepatitis B
Chronic hepatitis B virus (HBV) infection is the leading cause of liver cirrhosis and
hepatocellular carcinoma, estimated to be globally responsible for∼ 800,000 deaths …
hepatocellular carcinoma, estimated to be globally responsible for∼ 800,000 deaths …
Characterization of hepatitis B precore/core-related antigens
X Hong, L Luckenbaugh, M Mendenhall… - Journal of …, 2021 - Am Soc Microbiol
Current therapies rarely cure chronic hepatitis B virus (HBV) infection due to the persistence
of the viral episome, the covalently closed circular DNA (cccDNA), in hepatocytes. The …
of the viral episome, the covalently closed circular DNA (cccDNA), in hepatocytes. The …
Multiple roles of PP2A binding motif in hepatitis B virus core linker and PP2A in regulating core phosphorylation state and viral replication
Hepatitis B virus (HBV) capsid or core protein (HBc) contains an N-terminal domain (NTD)
and a C-terminal domain (CTD) connected by a short linker peptide. HBc plays a critical role …
and a C-terminal domain (CTD) connected by a short linker peptide. HBc plays a critical role …
[HTML][HTML] Critical updates on chronic hepatitis B virus infection in 2021
CA Philips, R Ahamed, JK Abduljaleel, S Rajesh… - Cureus, 2021 - ncbi.nlm.nih.gov
Chronic hepatitis B virus (HBV) infection is a global healthcare burden in the form of chronic
liver disease, cirrhosis, liver failure and liver cancer. There is no definite cure for the virus …
liver disease, cirrhosis, liver failure and liver cancer. There is no definite cure for the virus …
Hepatitis B virus–host interactions and novel targets for viral cure
G Ligat, ER Verrier, M Nassal, TF Baumert - Current opinion in virology, 2021 - Elsevier
Chronic infection with HBV is a major cause of advanced liver disease and hepatocellular
carcinoma. Nucleos (t) ide analogues effectively control HBV replication but viral cure is …
carcinoma. Nucleos (t) ide analogues effectively control HBV replication but viral cure is …
Early steps of hepatitis B life cycle: from capsid nuclear import to cccDNA formation
J Diogo Dias, N Sarica, C Neuveut - Viruses, 2021 - mdpi.com
Hepatitis B virus (HBV) remains a major public health concern, with more than 250 million
chronically infected people who are at high risk of developing liver diseases, including …
chronically infected people who are at high risk of developing liver diseases, including …
Major HBV splice variant encoding a novel protein important for infection
CY Chung, CP Sun, MH Tao, HL Wu, SH Wang… - Journal of …, 2024 - Elsevier
Background & Aims HBV expresses more than 10 spliced RNAs from the viral pregenomic
RNA, but their functions remain elusive and controversial. To address the function of HBV …
RNA, but their functions remain elusive and controversial. To address the function of HBV …