Next generation of immune checkpoint molecules in maternal‐fetal immunity

SJ Zhao, KP Muyayalo, J Luo, D Huang… - Immunological …, 2022 - Wiley Online Library
Successful pregnancy is a unique situation requires the maternal immune system to
recognize and tolerate a semi‐identical fetus and allow normal invasion of trophoblast cells …

Insight into the key points of preeclampsia pathophysiology: uterine artery remodeling and the role of microRNAs

K Pankiewicz, A Fijałkowska, T Issat… - International journal of …, 2021 - mdpi.com
Preeclampsia affects about 3–8% of all pregnancies. It represents a complex and
multifaceted syndrome with at least several potential pathways leading to the development …

Effects of Gestational Arsenic Exposures on Placental and Fetal Development in Mice: The Role of Cyr61

YP Song, JW Lv, ZC Zhang, QH Qian… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Several epidemiological investigations demonstrated that maternal arsenic
(As) exposure elevated risk of fetal growth restriction (FGR), but the mechanism remains …

Genetic associations of circulating cardiovascular proteins with gestational hypertension and preeclampsia

A Schuermans, B Truong, M Ardissino… - JAMA …, 2024 - jamanetwork.com
Importance Hypertensive disorders of pregnancy (HDPs), including gestational hypertension
and preeclampsia, are important contributors to maternal morbidity and mortality worldwide …

Dietary Folic Acid Supplementation Attenuates Maternal High-Fat Diet-Induced Fetal Intrauterine Growth Retarded via Ameliorating Placental Inflammation and …

H Zhang, X Zhang, Y Wang, X Zhao, L Zhang, J Li… - Nutrients, 2023 - mdpi.com
The placenta is particularly susceptible to inflammation and oxidative stress, leading to
placental vascular dysfunction and placental insufficiency, which is associated with fetal …

Medawar's PostEra: galectins emerged as key players during fetal-maternal glycoimmune adaptation

E Menkhorst, NG Than, U Jeschke… - Frontiers in …, 2021 - frontiersin.org
Lectin-glycan interactions, in particular those mediated by the galectin family, regulate many
processes required for a successful pregnancy. Over the past decades, increasing evidence …

Elevated galectin-3 levels detected in women with hyperglycemia during early and mid-pregnancy antagonizes high glucose− induced trophoblast cells apoptosis via …

Y Deng, H Jin, J Ning, D Cui, M Zhang, H Yang - Molecular Medicine, 2023 - Springer
Objective This study was to evaluate plasma galectin-3 levels from early pregnancy to
delivery and explore the effects of galectin-3 on the function of trophoblast cells under high …

A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia

SM Ghorbanpour, C Richards, D Pienaar… - Cellular and Molecular …, 2023 - Springer
Preeclampsia is a pregnancy-specific cardiovascular disorder, involving significant maternal
endothelial dysfunction. Although inappropriate placentation due to aberrant angiogenesis …

Roles of N-linked glycosylation and glycan-binding proteins in placentation: trophoblast infiltration, immunomodulation, angiogenesis, and pathophysiology

Z Huang, PF Lai, ATH Cocker… - Biochemical Society …, 2023 - portlandpress.com
Protein N-linked glycosylation is a structurally diverse post-translational modification that
stores biological information in a larger order of magnitude than other post-translational …

Galectins: important regulators in normal and pathologic pregnancies

M Chen, JL Shi, ZM Zheng, Z Lin, MQ Li… - International Journal of …, 2022 - mdpi.com
Galectins (Gal) are characterized by their affinity for galactoside structures on
glycoconjugates. This relationship is mediated by carbohydrate recognition domains, which …