Hallmarks of cardiovascular ageing

M Abdellatif, PP Rainer, S Sedej… - Nature Reviews …, 2023 - nature.com
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

The structure and function of the Na, K-ATPase isoforms in health and disease

MV Clausen, F Hilbers, H Poulsen - Frontiers in physiology, 2017 - frontiersin.org
The sodium and potassium gradients across the plasma membrane are used by animal cells
for numerous processes, and the range of demands requires that the responsible ion pump …

[PDF][PDF] 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

P Kirchhof, S Benussi, D Kotecha… - Polish Heart …, 2016 - journals.viamedica.pl
Komisję ESC ds. Wytycznych Postępowania nadzoruje i koordynuje przygotowywanie
nowych wytycznych i stanowisk przez grupy robocze i inne grupy ekspertów. Komitet jest …

Effect of digoxin vs bisoprolol for heart rate control in atrial fibrillation on patient-reported quality of life: the RATE-AF randomized clinical trial

D Kotecha, KV Bunting, SK Gill, S Mehta, M Stanbury… - Jama, 2020 - jamanetwork.com
Importance There is little evidence to support selection of heart rate control therapy in
patients with permanent atrial fibrillation, in particular those with coexisting heart failure …

Identification and characterization of Cardiac Glycosides as senolytic compounds

F Triana-Martínez, P Picallos-Rabina… - Nature …, 2019 - nature.com
Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the
causal involvement of senescence in aging and offer therapeutic interventions. Here we …

A cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis

E Carroll, B Ravi Gopal, I Raghavan… - Nature …, 2023 - nature.com
Digoxin extracted from the foxglove plant is a widely prescribed natural product for treating
heart failure. It is listed as an essential medicine by the World Health Organization. However …

Consumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers: the RATE-AF randomized trial

SK Gill, A Barsky, X Guan, KV Bunting, A Karwath… - Nature Medicine, 2024 - nature.com
Consumer-grade wearable technology has the potential to support clinical research and
patient management. Here, we report results from the RATE-AF trial wearables study, which …

[PDF][PDF] 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

F Casselman, A Coca, R De Caterina… - European heart …, 2016 - academia.edu
Surveys and registries are needed to verify that real-life daily practice is in keeping with what
is recommended in the guidelines, thus completing the loop between clinical research …

Pharmacovigilance of herbal medicines: Concerns and future prospects

A Choudhury, PA Singh, N Bajwa, S Dash… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance The use of herbal medicines for prophylaxis, prevention,
and treatment of various ailments is rising throughout the world because they are thought to …

Digoxin and mortality in patients with atrial fibrillation

RD Lopes, R Rordorf, GM De Ferrari, S Leonardi… - Journal of the American …, 2018 - jacc.org
Background: Digoxin is widely used in patients with atrial fibrillation (AF). Objectives: The
goal of this paper was to explore whether digoxin use was independently associated with …