Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq
Cells secrete numerous bioactive molecules that are essential for the function of healthy
organisms. However, scalable methods are needed to link individual cell secretions to their …
organisms. However, scalable methods are needed to link individual cell secretions to their …
Decoding the functional impact of the cancer genome through protein–protein interactions
Acquisition of genomic mutations enables cancer cells to gain fitness advantages under
selective pressure and, ultimately, leads to oncogenic transformation. Interestingly, driver …
selective pressure and, ultimately, leads to oncogenic transformation. Interestingly, driver …
Beyond single cells: microfluidics empowering multiomics analysis
Single-cell multiomics technologies empower simultaneous measurement of multiple types
of molecules within individual cells, providing a more profound comprehension compared …
of molecules within individual cells, providing a more profound comprehension compared …
Therapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis
Y Wang, J Han, G Yang, S Zheng, G Zhou, X Liu… - Nature …, 2024 - nature.com
Mucus injury associated with goblet cell (GC) depletion constitutes an early event in
inflammatory bowel disease (IBD). Using single-cell sequencing to detect critical events in …
inflammatory bowel disease (IBD). Using single-cell sequencing to detect critical events in …
Spatially resolved subcellular protein–protein interactomics in drug-perturbed lung-cancer cultures and tissues
S Cai, T Hu, A Venkataraman… - Nature Biomedical …, 2024 - nature.com
Protein–protein interactions (PPIs) regulate signalling pathways and cell phenotypes, and
the visualization of spatially resolved dynamics of PPIs would thus shed light on the …
the visualization of spatially resolved dynamics of PPIs would thus shed light on the …
Single-cell chemoproteomics identifies metastatic activity signatures in breast cancer
K Smitha Pillai, O Laxton, G Li, J Lin, O Karginova… - Science …, 2024 - science.org
Protein activity state, rather than protein or mRNA abundance, is a biologically regulated
and relevant input to many processes in signaling, differentiation, development, and …
and relevant input to many processes in signaling, differentiation, development, and …
scMHNN: a novel hypergraph neural network for integrative analysis of single-cell epigenomic, transcriptomic and proteomic data
Technological advances have now made it possible to simultaneously profile the changes of
epigenomic, transcriptomic and proteomic at the single cell level, allowing a more unified …
epigenomic, transcriptomic and proteomic at the single cell level, allowing a more unified …
[HTML][HTML] Machine learning integrative approaches to advance computational immunology
The study of immunology, traditionally reliant on proteomics to evaluate individual immune
cells, has been revolutionized by single-cell RNA sequencing. Computational …
cells, has been revolutionized by single-cell RNA sequencing. Computational …
Proximity sequencing for the detection of mRNA, extracellular proteins and extracellular protein complexes in single cells
Complex cellular functions occur via the coordinated formation and dissociation of protein
complexes. Functions such as the response to a signaling ligand can incorporate dozens of …
complexes. Functions such as the response to a signaling ligand can incorporate dozens of …
From single cell to spatial multi-omics: unveiling molecular mechanisms in dynamic and heterogeneous systems
Highlights•Recent progress in single-cell and spatial technologies.•Applications of single-
cell and spatial technology in biomedical and environmental studies.•Spatial multi-omics …
cell and spatial technology in biomedical and environmental studies.•Spatial multi-omics …