[HTML][HTML] Anti-CD73 antibody activates human B cells, enhances humoral responses and induces redistribution of B cells in patients with cancer
Background CD73 is widely expressed on immune cells playing a critical role in
immunomodulatory functions including cell adhesion and migration, as a costimulatory …
immunomodulatory functions including cell adhesion and migration, as a costimulatory …
Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor …
BP Kaistha, G Kar, A Dannhorn, A Watkins… - Cancer Biology & …, 2024 - Taylor & Francis
ABSTRACT CD73 is a cell surface 5'nucleotidase (NT5E) and key node in the catabolic
process generating immunosuppressive adenosine in cancer. Using a murine monoclonal …
process generating immunosuppressive adenosine in cancer. Using a murine monoclonal …
Pharmacology, pharmacokinetics, and toxicity characterization of a novel anti-CD73 therapeutic antibody IBI325 for cancer immunotherapy
Y Zhou, H Shen, M Wu, J Wang, Z Wu, F Fu… - International Journal of …, 2023 - Elsevier
It is an intriguing approach to target the ecto-5′-nucleotidase CD73 to confer synergetic
beneficial survival in cancer patients, along with clinically established immunotherapy …
beneficial survival in cancer patients, along with clinically established immunotherapy …