Glycolipids are ubiquitous and biologically important molecules and are involved in diverse
biological functions and exhibit biosurfactant applications due to their surface-active and …

Carbohydrate‐based drug discovery has gained more and more attention during the last few
decades. Resin glycoside is a kind of novel and complex glycolipids mainly distributed in …

Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with
single-digit nanomolar potency. However, its biological and pharmacological properties …

Two new ring-size-varying analogues (2 and 3) of ipomoeassin F were synthesized and
evaluated. Improved cytotoxicity (IC50: from 1.8 nM) and in vitro protein translocation …

Murucoidins IV and V, two bioactive resin glycosides with complex yet similar structures
isolated from the morning glory family, were synthesized in a convergent manner. All of the …

The exploration of hybridization emerges as a potent tool in advancing drug discovery
research, with a significant emphasis on carbohydrate-containing hybrid scaffolds. Evidence …

Tricolorin A, a bioactive resin glycoside, was synthesized stepwise or in one pot based on
interrupted Pummerer reaction-mediated (IPRm) glycosylation. The stepwise synthesis …

Ipomoeassin F (Ipom-F) is a plant-derived macrocyclic resin glycoside that potently inhibits
cancer cell growth through blockage of Sec61-mediated protein translocation at the …

The plant-derived macrocyclic resin glycoside ipomoeassin F (Ipom-F) binds to Sec61α and
significantly disrupts multiple aspects of Sec61-mediated protein biogenesis at the …

The author describes his 60-year career in studying the chemistry of natural products, which
includes structural, synthetic, and biosynthetic studies of natural products ranging from …