[HTML][HTML] The limitless future of RNA therapeutics
Recent advances in the generation, purification and cellular delivery of RNA have enabled
development of RNA-based therapeutics for a broad array of applications. RNA therapeutics …
development of RNA-based therapeutics for a broad array of applications. RNA therapeutics …
[HTML][HTML] Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
S Zhang, J Shen, D Li, Y Cheng - Theranostics, 2021 - ncbi.nlm.nih.gov
CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …
however, the translation of this biotechnology into therapy has been hindered by efficient …
Microfluidic formulation of nanoparticles for biomedical applications
SJ Shepherd, D Issadore, MJ Mitchell - Biomaterials, 2021 - Elsevier
Nanomedicine has made significant advances in clinical applications since the late-20th
century, in part due to its distinct advantages in biocompatibility, potency, and novel …
century, in part due to its distinct advantages in biocompatibility, potency, and novel …
The current state and future directions of RNAi-based therapeutics
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
Self-protected DNAzyme walker with a circular bulging DNA shield for amplified imaging of miRNAs in living cells and mice
Abnormal expression of miRNAs is often detected in various human cancers. DNAzyme
machines combined with gold nanoparticles (AuNPs) hold promise for detecting specific …
machines combined with gold nanoparticles (AuNPs) hold promise for detecting specific …
Advances in biomaterials for drug delivery
OS Fenton, KN Olafson, PS Pillai… - Advanced …, 2018 - Wiley Online Library
Advances in biomaterials for drug delivery are enabling significant progress in biology and
medicine. Multidisciplinary collaborations between physical scientists, engineers, biologists …
medicine. Multidisciplinary collaborations between physical scientists, engineers, biologists …
Enabling technologies for personalized and precision medicine
Individualizing patient treatment is a core objective of the medical field. Reaching this
objective has been elusive owing to the complex set of factors contributing to both disease …
objective has been elusive owing to the complex set of factors contributing to both disease …
miRNA deregulation in cancer cells and the tumor microenvironment
R Rupaimoole, GA Calin, G Lopez-Berestein, AK Sood - Cancer discovery, 2016 - AACR
Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …
Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …
and recombinant proteins, poses substantial challenges owing to their large size and …
Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles
Inorganic nanoparticles provide multipurpose platforms for a broad range of delivery
applications. Intrinsic nanoscopic properties provide access to unique magnetic and optical …
applications. Intrinsic nanoscopic properties provide access to unique magnetic and optical …