Acral and mucosal melanomas are extremely rare in Caucasians; however, they are the
predominant melanoma subtypes in Asians and other non-Caucasian populations. Acral …

Mucosal melanoma is a rare and aggressive subtype of melanoma that has a less favorable
prognosis due to the lack of understanding and identification of oncogenic drivers. Recently …

Until recently, distant metastatic melanoma was considered refractory to systemic therapy. A
better understanding of the interactions between tumors and the immune system and the …

Preclinical studies have suggested that epigenetic therapy could enhance immunogenicity
of cancer cells. We report the results of the PEMDAC phase 2 clinical trial (n= 29; …

PURPOSE Emerging evidence suggests a correlation between the tumor mutational burden
(TMB) and the response to programmed cell death-1 protein (PD-1) monotherapy across …

Among Uveal Melanoma (UM) driver mutations, those involving GNAQ or GNA11 genes are
the most frequent, while a minor fraction of tumors bears mutations in the PLCB4 or …

Background Programmed cell death receptor‐1 (PD‐1) monotherapy is a standard treatment
for advanced cutaneous melanoma, but its efficacy and toxicity are defined in white …

PURPOSE Mucosal melanoma (MM) is a highly vascularized tumor with an extremely poor
prognosis. In this randomized, open-label, phase II study, we characterized the efficacy and …

Simple Summary This review provides an updated overview about molecular features,
clinical advancements and therapeutic directions of the primary mucosal melanoma which …

Simple Summary Around 50% of patients with uveal melanoma (UM) still develop metastatic
disease. Despite recent advances in the diagnosis and prognosis of UM, improvements in …