Vanadium in biological action: chemical, pharmacological aspects, and metabolic implications in diabetes mellitus

S Treviño, A Díaz, E Sánchez-Lara… - Biological trace element …, 2019 - Springer
Vanadium compounds have been primarily investigated as potential therapeutic agents for
the treatment of various major health issues, including cancer, atherosclerosis, and …

The role of vanadium in biology

D Rehder - Metallomics, 2015 - academic.oup.com
Vanadium is special in at least two respects: on the one hand, the tetrahedral anion
vanadate (v) is similar to the phosphate anion; vanadate can thus interact with various …

Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities

A Levina, DC Crans, PA Lay - Coordination Chemistry Reviews, 2017 - Elsevier
Studies of metal uptake, metabolism and excretion by single bacterial, yeast, plant and
animal cells is a widespread area of research, yet little is known about the reactivity and …

Vanadium (IV) complexes of salicylaldehyde-based furoic acid hydrazones: Synthesis, BSA binding and in vivo antidiabetic potential

A Zahirović, S Hadžalić, A Višnjevac, M Fočak… - Journal of inorganic …, 2023 - Elsevier
Solution synthesis afforded five novel neutral heteroleptic octahedral paramagnetic
mononuclear oxidovanadium (IV) complexes of general composition [VO (bpy) L], where L is …

Binding of vanadium ions and complexes to proteins and enzymes in aqueous solution

JC Pessoa, MFA Santos, I Correia, D Sanna… - Coordination Chemistry …, 2021 - Elsevier
The understanding of the role of vanadium enzymes and of vanadium compounds (VCs) in
biology, as well as the design of new vanadium-based species for catalysis, materials …

Vanadium and proteins: Uptake, transport, structure, activity and function

JC Pessoa, E Garribba, MFA Santos… - Coordination chemistry …, 2015 - Elsevier
Vanadium is an element ubiquitously present in our planet's crust and thus there are several
organisms that use vanadium for activity or function of proteins. Examples are the vanadium …

Developing vanadium as an antidiabetic or anticancer drug: A clinical and historical perspective

DC Crans, L Henry, G Cardiff, BI Posner - Met. Ions Life Sci, 2019 - degruyter.com
Vanadium has been known for centuries to have beneficial effects on health and has the
potential to be used as an alternative to other diabetic and anticancer medicines. The …

Therapeutic properties of vanadium complexes

AA Sharfalddin, IM Al-Younis, HA Mohammed… - Inorganics, 2022 - mdpi.com
Vanadium is a hard, silver-grey transition metal found in at least 60 minerals and fossil fuel
deposits. Its oxide and other vanadium salts are toxic to humans, but the toxic effects depend …

Antidiabetic, chemical, and physical properties of organic vanadates as presumed transition-state inhibitors for phosphatases

DC Crans - The Journal of Organic Chemistry, 2015 - ACS Publications
Studies of antidiabetic vanadium compounds, specifically the organic vanadate esters, are
reviewed with regard to their chemistry and biological properties. The compounds are …

Perspectives for vanadium in health issues

D Rehder - Future medicinal chemistry, 2016 - Taylor & Francis
Vanadium is omnipresent in trace amounts in the environment, in food and also in the
human body, where it might serve as a regulator for phosphate-dependent proteins …