HLA-DR15 Haplotype and Multiple Sclerosis: A HuGE Review

H Schmidt, D Williamson… - American journal of …, 2007 - academic.oup.com
An association between multiple sclerosis (MS) and the human leukocyte antigen (HLA)
complex, a dense cluster of genes on the short arm of chromosome 6, was first noted over …

Insights into the immunopathogenesis of multiple sclerosis

N Hellings, J Raus, P Stinissen - Immunologic research, 2002 - Springer
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS). Significant progress has been made in our understanding of the etiology of MS. MS …

Genetic predisposition to multiple sclerosis as revealed by immunoprinting

C Epplen, S Jäckel, EJM Santos, M D'Souza… - Annals of …, 1997 - Wiley Online Library
This study was designed to examine the immunogenetic background predisposing to
multiple sclerosis (MS). Three hundred fifty‐eight clinically well‐characterized MS patients …

New candidate loci for multiple sclerosis susceptibility revealed by a whole genome association screen in a Belgian population

A Goris, S Sawcer, K Vandenbroeck, H Carton… - Journal of …, 2003 - Elsevier
We have completed a whole genome screen for association with multiple sclerosis (MS) in a
Belgian population. The 6000 microsatellite markers provided through the Genetic …

The CTLA4+ 49 A/G* G–CT60* G haplotype is associated with susceptibility to multiple sclerosis in Flanders

V Suppiah, I Alloza, S Heggarty, A Goris… - Journal of …, 2005 - Elsevier
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system white
matter characterized by inflammation, demyelination and axonal damage. The cytotoxic T …

Sequence variation in the human T‐cell receptor loci

R Mackelprang, CS Carlson… - Immunological …, 2002 - Wiley Online Library
Identifying common sequence variations known as single nucleotide polymorphisms (SNPs)
in human populations is one of the current objectives of the human genome project. Nearly 3 …

Susceptibility to relapsing-progressive multiple sclerosis is associated with inheritance of genes linked to the variable region of the TcR β locus: Use of affected family …

MK Hockertz, DW Paty, SS Beall - The American Journal of Human …, 1998 - cell.com
We tested the hypothesis that susceptibility to relapsing-progressive (RP)(but not to
relapsing-remitting [RR]) multiple sclerosis (MS) is associated with a gene linked to the TcR …

Immune system genes in multiple sclerosis: genetic association and linkage analyses on TCRβ, IGH, IFN-γ and IL-1ra/IL-1β loci

K Wansen, T Pastinen, S Kuokkanen, J Wikström… - Journal of …, 1997 - Elsevier
The role of genetic factors in the etiology of multiple sclerosis (MS) has been clearly
demonstrated but the loci determining susceptibility to this disease remain largely …

Importance of HLA-DRB1 and DQA1 genes and of the amino acid polymorphisms in the functional domain of DRβ1 chain in multiple sclerosis

MZ Ghabanbasani, XX Gu, M Spaepen… - Journal of …, 1995 - Elsevier
The association of some HLA class II alleles with multiple sclerosis (MS) has been amply
documented. In the present study the role of HLA class II haplotypes and genotypes and of …

TCR β polymorphisms and multiple sclerosis

DA Dyment, JL Steckley, K Morrison, CJ Willer… - Genes & …, 2004 - nature.com
A total of 267 families with two or more siblings with multiple sclerosis (MS) were genotyped
with 14 restriction fragment length polymorphisms at the TCR β locus. A nonparametric …