The ability of vertebrates to regenerate amputated appendages is increasingly well-
understood at the cellular level. Cells mediating an innate immune response and …

This review explores the historical and current state of our knowledge about urodele limb
regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of …

The largest published phylogenetic analysis of early limbed vertebrates (Ruta M, Coates MI.
2007. Journal of Systematic Palaeontology 5: 69–122) recovered, for example …

Salamanders and lungfishes are the only sarcopterygians (lobe-finned vertebrates) capable
of paired appendage regeneration, regardless of the amputation level. Among …

Throughout the animal kingdom regenerative ability varies greatly from species to species,
and even tissue to tissue within the same organism. The sheer diversity of structures and …

This review elaborates the idea that organ regeneration derives from specific evolutionary
histories of vertebrates. Regenerative ability depends on genomic regulation of genes …

Salamanders are the only living tetrapods capable of fully regenerating limbs. The discovery
of salamander lineage-specific genes (LSGs) expressed during limb regeneration suggests …

Among extant tetrapods, salamanders are unique in showing a reversed preaxial polarity in
patterning of the skeletal elements of the limbs, and in displaying the highest capacity for …

Limb development in salamanders differs from other tetrapods in that the first digits to form
are the two most anterior (preaxial dominance). This has been proposed as a salamander …

Among tetrapods, only salamanders can regenerate their limbs and tails throughout life. This
amazing regenerative ability has attracted the attention of scientists for hundreds of years …