Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …

Tuberculosis (TB) is the leading killer among all infectious diseases worldwide despite
extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer …

Effective tuberculosis treatment requires at least 6 months of combination therapy.
Alterations in the physiological state of the bacterium during infection are thought to reduce …

ABSTRACT Interleukin-1 (IL-1) is a key player in the immune response to pathogens due to
its role in promoting inflammation and recruiting immune cells to the site of infection. In …

Increasing evidence supports the repositioning of beta-lactams for tuberculosis (TB) therapy,
but further research on their interaction with conventional anti-TB agents is still warranted …

Oxylipins are major immunomodulating mediators, yet studies of inflammation focus mainly
on cytokines. Here, using a standardized whole-blood stimulation system, we characterized …

Host genetics plays an important role in determining the outcome of Mycobacterium
tuberculosis infection. We previously found that Collaborative Cross (CC) mouse strains …

Mycobacterium tuberculosis (Mtb) is a bacterium that exclusively resides in human hosts
and remains a dominant cause of morbidity and mortality among infectious diseases …

Interferon gamma (IFN-γ) restricts the intracellular replication of many pathogens, but the
mechanism by which IFN-γ confers cell-intrinsic pathogen resistance remains unclear. For …

The W-Beijing strain family is globally distributed and is associated with multidrug-resistant
tuberculosis (TB) and treatment failure. Therefore, in this study, we examined the …