Review of methods for intraoperative margin detection for breast conserving surgery
Breast conserving surgery (BCS) is an effective treatment for early-stage cancers as long as
the margins of the resected tissue are free of disease according to consensus guidelines for …
the margins of the resected tissue are free of disease according to consensus guidelines for …
FLIM as a promising tool for cancer diagnosis and treatment monitoring
Fluorescence lifetime imaging microscopy (FLIM) has been rapidly developed over the past
30 years and widely applied in biomedical engineering. Recent progress in fluorophore …
30 years and widely applied in biomedical engineering. Recent progress in fluorophore …
Probing organoid metabolism using fluorescence lifetime imaging microscopy (FLIM): The next frontier of drug discovery and disease understanding
Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …
Intraoperative margin assessment in oral and oropharyngeal cancer using label-free fluorescence lifetime imaging and machine learning
Objective: To demonstrate the diagnostic ability of label-free, point-scanning, fiber-based
Fluorescence Lifetime Imaging (FLIm) as a means of intraoperative guidance during oral …
Fluorescence Lifetime Imaging (FLIm) as a means of intraoperative guidance during oral …
Intra-operative spectroscopic assessment of surgical margins during breast conserving surgery
Background In over 20% of breast conserving operations, postoperative pathological
assessment of the excised tissue reveals positive margins, requiring additional surgery …
assessment of the excised tissue reveals positive margins, requiring additional surgery …
In situ Raman spectroscopy and machine learning unveil biomolecular alterations in invasive breast cancer
S David, T Tran, F Dallaire, G Sheehy… - Journal of …, 2023 - spiedigitallibrary.org
Significance As many as 60% of patients with early stage breast cancer undergo breast-
conserving surgery. Of those, 20% to 35% need a second surgery because of incomplete …
conserving surgery. Of those, 20% to 35% need a second surgery because of incomplete …
Real-time diagnosis and visualization of tumor margins in excised breast specimens using fluorescence lifetime imaging and machine learning
Tumor-free surgical margins are critical in breast-conserving surgery. In up to 38% of the
cases, however, patients undergo a second surgery since malignant cells are found at the …
cases, however, patients undergo a second surgery since malignant cells are found at the …
Mesoscopic fluorescence lifetime imaging: Fundamental principles, clinical applications and future directions
Fluorescence lifetime imaging (FLIm) is an optical spectroscopic imaging technique capable
of real‐time assessments of tissue properties in clinical settings. Label‐free FLIm is sensitive …
of real‐time assessments of tissue properties in clinical settings. Label‐free FLIm is sensitive …
Deep learning in macroscopic diffuse optical imaging
Significance: Biomedical optics system design, image formation, and image analysis have
primarily been guided by classical physical modeling and signal processing methodologies …
primarily been guided by classical physical modeling and signal processing methodologies …
Engineering approaches for breast cancer diagnosis: a review
Breast cancer is a leading cause of mortality among women. The patient's survival rate is
uncertain due to the limitations in the accuracy of diagnosis and effective monitoring during …
uncertain due to the limitations in the accuracy of diagnosis and effective monitoring during …