Epigenetic alterations in depression and antidepressant treatment
Epigenetic modifications control chromatin structure and function, and thus mediate changes
in gene expression, ultimately influencing protein levels. Recent research indicates that …
in gene expression, ultimately influencing protein levels. Recent research indicates that …
Genome-wide profiling of yeast DNA: RNA hybrid prone sites with DRIP-chip
DNA: RNA hybrid formation is emerging as a significant cause of genome instability in
biological systems ranging from bacteria to mammals. Here we describe the genome-wide …
biological systems ranging from bacteria to mammals. Here we describe the genome-wide …
Transcriptional regulatory proteins in central carbon metabolism of Pichia pastoris and Saccharomyces cerevisiae
Ö Kalender, P Çalık - Applied Microbiology and Biotechnology, 2020 - Springer
Abstract System-wide interactions in living cells and discovery of the diverse roles of
transcriptional regulatory proteins that are mediator proteins with catalytic domains and …
transcriptional regulatory proteins that are mediator proteins with catalytic domains and …
[HTML][HTML] RNA Pol II length and disorder enable cooperative scaling of transcriptional bursting
Summary RNA polymerase II (RNA Pol II) contains a disordered C-terminal domain (CTD)
whose length enigmatically correlates with genome size. The CTD is crucial to eukaryotic …
whose length enigmatically correlates with genome size. The CTD is crucial to eukaryotic …
Transcription activation depends on the length of the RNA polymerase II C‐terminal domain
A Sawicka, G Villamil, M Lidschreiber, X Darzacq… - The EMBO …, 2021 - embopress.org
Abstract Eukaryotic RNA polymerase II (Pol II) contains a tail‐like, intrinsically disordered
carboxy‐terminal domain (CTD) comprised of heptad‐repeats, that functions in coordination …
carboxy‐terminal domain (CTD) comprised of heptad‐repeats, that functions in coordination …
Different phosphoisoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner
The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II)
orchestrates dynamic recruitment of specific cellular machines during different stages of …
orchestrates dynamic recruitment of specific cellular machines during different stages of …
CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells
RM Horvath, ZL Brumme, I Sadowski - Journal of Virology, 2023 - Am Soc Microbiol
Latent HIV-1 provirus represents the barrier toward a cure for infection and is dependent
upon the host RNA Polymerase (Pol) II machinery for reemergence. Here, we find that …
upon the host RNA Polymerase (Pol) II machinery for reemergence. Here, we find that …
[HTML][HTML] The Ess1 prolyl isomerase: traffic cop of the RNA polymerase II transcription cycle
SD Hanes - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2014 - Elsevier
Ess1 is a prolyl isomerase that regulates the structure and function of eukaryotic RNA
polymerase II. Ess1 works by catalyzing the cis/trans conversion of pSer5–Pro6 bonds, and …
polymerase II. Ess1 works by catalyzing the cis/trans conversion of pSer5–Pro6 bonds, and …
Sub1 contacts the RNA polymerase II stalk to modulate mRNA synthesis
M Garavís, N González-Polo… - Nucleic acids …, 2017 - academic.oup.com
Biogenesis of messenger RNA is critically influenced by the phosphorylation state of the
carboxy-terminal domain (CTD) in the largest RNA polymerase II (RNAPII) subunit. Several …
carboxy-terminal domain (CTD) in the largest RNA polymerase II (RNAPII) subunit. Several …
Gene transcription as a limiting factor in protein production and cell growth
Cell growth is driven by the synthesis of proteins, genes, and other cellular components.
Defining processes that limit biosynthesis rates is fundamental for understanding the …
Defining processes that limit biosynthesis rates is fundamental for understanding the …