A review of the ethnopharmacology, phytochemistry, pharmacology and toxicology of Fructus Gardeniae (Zhi-zi)

J Tian, S Qin, J Han, J Meng, A Liang - Journal of Ethnopharmacology, 2022 - Elsevier
Abstract Ethnopharmacological relevance Fructus Gardeniae (FG) is the dried fruit of
Gardenia jasminoides Ellis (GjE), which belongs to the family Rubiaceae. FG has a long …

Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: More friend than foe

X Fan, L Lin, B Cui, T Zhao, L Mao, Y Song… - Pharmacological …, 2020 - Elsevier
Genipin is an aglycone derived from the geniposide, the most abundant iridoid glucoside
constituent of Gardenia jasminoides Ellis. For decades, genipin is the focus of studies as a …

[HTML][HTML] Geniposide ameliorates glucocorticoid-induced osteoblast apoptosis by activating autophagy

J Huang, Y Ye, Y Xiao, Q Ren, Q Zhou, M Zhong… - Biomedicine & …, 2022 - Elsevier
Long-term exposure to glucocorticoid (GC) contributes to the development of osteoporosis
(OP), which is correlated with the risk of fracture. Pathologically, GC-induced bone loss is …

Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases

D Ran, W Hong, W Yan, W Mengdie - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance Geniposide (GE) is ubiquitous in nearly 40 species of
plants, among which Gardenia jasminoides J. Ellis has the highest content, and has been …

Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses

J Liu, YF Lu, Q Wu, SF Xu, FG Shi… - Liver …, 2019 - Wiley Online Library
Oleanolic acid (OA) is a triterpenoid that exists widely in fruits, vegetables and medicinal
herbs. OA is included in some dietary supplements and is used as a complementary and …

Optimized therapeutic potential of Yinchenhao decoction for cholestatic hepatitis by combined network meta-analysis and network pharmacology

S Luo, M Huang, X Lu, M Zhang, H Xiong, X Tan… - Phytomedicine, 2024 - Elsevier
Background Cholestatic hepatitis is recognized as a significant contributor to the
development of liver fibrosis and cirrhosis. As a well-known classic formula for the treatment …

Bidirectional effects of geniposide in liver injury: preclinical evidence construction based on meta-analysis

X Zeng, J Jiang, S Liu, Q Hu, S Hu, J Zeng, X Ma… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Gardenia jasminoides J. Ellis is widely used to treat liver
diseases in traditional Chinese medicine. Geniposide, a major active constituent of …

Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids

J Liu, Y Li, C Sun, S Liu, Y Yan, H Pan, M Fan… - Pharmacological …, 2020 - Elsevier
Hypercholesterolemia is the main risk factor to threaten human health and geniposide has
been found to have hypolipidemic functions. However, its underlying mechanism is not …

Geniposide ameliorated dexamethasone-induced cholesterol accumulation in osteoblasts by mediating the GLP-1R/ABCA1 Axis

Y Zheng, Y Xiao, D Zhang, S Zhang, J Ouyang, L Li… - Cells, 2021 - mdpi.com
Background: Overexposure to glucocorticoid (GC) produces various clinical complications,
including osteoporosis (OP), dyslipidemia, and hypercholesterolemia. Geniposide (GEN) is …

Geniposide for treating atherosclerotic cardiovascular disease: a systematic review on its biological characteristics, pharmacology, pharmacokinetics, and toxicology

D Li, X Li, X Zhang, J Chen, Z Wang, Z Yu, M Wu… - Chinese Medicine, 2024 - Springer
In recent years, the prevalence and fatality rates of atherosclerotic cardiovascular disease
have not only shown a consistent rise that cannot be ignored, but have also become a …