Spatial pharmacology using mass spectrometry imaging

P Rajbhandari, TV Neelakantan, N Hosny… - Trends in …, 2024 - cell.com
The emerging and powerful field of spatial pharmacology can map the spatial distribution of
drugs and their metabolites, as well as their effects on endogenous biomolecules including …

Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging

ML Spruill, M Maletic-Savatic, H Martin, F Li… - Biochemical …, 2022 - Elsevier
Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …

Spatial segmentation of mass spectrometry imaging data by combining multivariate clustering and univariate thresholding

H Hu, R Yin, HM Brown, J Laskin - Analytical chemistry, 2021 - ACS Publications
Spatial segmentation partitions mass spectrometry imaging (MSI) data into distinct regions,
providing a concise visualization of the vast amount of data and identifying regions of …

Imaging of N-linked glycans in biological tissue sections using nanospray desorption electrospray ionization (nano-DESI) mass spectrometry

MR Weigand, AM Moore, H Hu, PM Angel… - Journal of the …, 2023 - ACS Publications
N-linked glycans are complex biomolecules vital to cellular functions that have been linked
to a wide range of pathological conditions. Mass spectrometry imaging (MSI) has been used …

Applications of ambient ionization mass spectrometry in 2022: An annual review

S Rankin‐Turner, P Sears… - Analytical Science …, 2023 - Wiley Online Library
The development of ambient ionization mass spectrometry (AIMS) has transformed
analytical science, providing the means of performing rapid analysis of samples in their …

A monolithic microfluidic probe for ambient mass spectrometry imaging of biological tissues

LX Jiang, M Polack, X Li, M Yang, D Belder, J Laskin - Lab on a Chip, 2023 - pubs.rsc.org
Ambient mass spectrometry imaging (MSI) is a powerful technique that allows for the
simultaneous mapping of hundreds of molecules in biological samples under atmospheric …

Multiple selected ion monitoring mode for sensitive imaging of eicosanoids in tissues using nanospray desorption electrospray ionization (nano-DESI) mass …

CD Huffstutler, DM Sanchez, MR Weigand, H Hu… - International Journal of …, 2023 - Elsevier
Nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI MSI)
enables sensitive label-free mapping of multiple classes of molecules in biological samples …

Quantitative mass spectrometry imaging: therapeutics & biomolecules

JH Holbrook, GE Kemper, AB Hummon - Chemical Communications, 2024 - pubs.rsc.org
Mass spectrometry imaging (MSI) has become increasingly utilized in the analysis of
biological molecules. MSI grants the ability to spatially map thousands of molecules within …

Nanospray Desorption Electrospray Ionization Mass Spectrometry Imaging (nano-DESI MSI): A Tutorial Review

M Iqfath, SN Wali, S Amer, E Hernly… - ACS Measurement …, 2024 - ACS Publications
Nanospray desorption electrospray ionization (nano-DESI) is a liquid-based ambient mass
spectrometry imaging (MSI) technique that enables visualization of analyte distributions in …

Intracellular spatiotemporal metabolism in connection to target engagement

J Zhang, Z Qiu, Y Zhang, G Wang, H Hao - Advanced Drug Delivery …, 2023 - Elsevier
The metabolism in eukaryotic cells is a highly ordered system involving various cellular
compartments, which fluctuates based on physiological rhythms. Organelles, as the smallest …