Glycopolymer nanobiotechnology

Y Miura, Y Hoshino, H Seto - Chemical reviews, 2016 - ACS Publications
Molecular recognition plays an important role in living systems. 1, 2 Representative
molecular recognitions in living organisms are saccharide− protein, protein− protein, and …

Glycosylated gold nanoparticles in point of care diagnostics: From aggregation to lateral flow

AN Baker, GW Hawker-Bond, PG Georgiou… - Chemical Society …, 2022 - pubs.rsc.org
Current point-of-care lateral flow immunoassays, such as the home pregnancy test, rely on
proteins as detection units (eg antibodies) to sense for analytes. Glycans play a fundamental …

Targeted and equally distributed delivery of mrna to organs with pentaerythritol-based one-component ionizable amphiphilic janus dendrimers

J Lu, EN Atochina-Vasserman, DS Maurya… - Journal of the …, 2023 - ACS Publications
Delivery of nucleic acids with viral and synthetic vectors has pioneered genetic
nanomedicine. Four-component lipid nanoparticles (LNPs) consisting of ionizable lipids …

One-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer delivery systems for mRNA

D Zhang, EN Atochina-Vasserman… - Journal of the …, 2021 - ACS Publications
Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine.
Both viral and synthetic vectors have been successfully employed for genetic delivery with …

The unexpected importance of the primary structure of the hydrophobic part of one-component ionizable amphiphilic Janus dendrimers in targeted mRNA delivery …

D Zhang, EN Atochina-Vasserman, J Lu… - Journal of the …, 2022 - ACS Publications
Viral and synthetic vectors for delivery of nucleic acids impacted genetic nanomedicine by
aiding the rapid development of the extraordinarily efficient Covid-19 vaccines. Access to …

Targeted delivery of mRNA with one-component ionizable amphiphilic Janus dendrimers

D Zhang, EN Atochina-Vasserman… - Journal of the …, 2021 - ACS Publications
Targeted and efficient delivery of nucleic acids with viral and synthetic vectors is the key step
of genetic nanomedicine. The four-component lipid nanoparticle synthetic delivery systems …

Multivalent glycosystems for human lectins

M Martínez-Bailén, J Rojo… - Chemical Society …, 2023 - pubs.rsc.org
Human lectins are involved in a wide variety of biological processes, both physiological and
pathological, which have attracted the interest of the scientific community working in the …

Engineering receptor-mediated transmembrane signaling in artificial and living cells

K Shi, C Song, Y Wang, R Chandrawati… - Communications …, 2023 - nature.com
Living cells possess a variety of transmembrane signaling systems that receive chemical
and physical cues from the environment and transduce this information into an intracellular …

Mimicking complex biological membranes and their programmable glycan ligands with dendrimersomes and glycodendrimersomes

SE Sherman, Q Xiao, V Percec - Chemical reviews, 2017 - ACS Publications
Synthetic vesicles have been assembled and coassembled from phospholipids, their
modified versions, and other single amphiphiles into liposomes, and from block copolymers …

Multivalent glycans for biological and biomedical applications

Y Kim, JY Hyun, I Shin - Chemical Society Reviews, 2021 - pubs.rsc.org
Recognition of glycans by proteins plays a crucial role in a variety of physiological
processes in cells and living organisms. In addition, interactions of glycans with proteins are …