Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory
hubs for a variety of signal transduction pathways. Despite having a conserved basic …

The primary cilium is an antenna-like organelle assembled on most types of quiescent and
differentiated mammalian cells. This immotile structure is essential for interpreting …

The assembly of the axoneme, the structural scaffold of cilia and flagella, requires
translocation of a vast quantity of tubulin into the growing cilium, but the mechanisms that …

Cilia and flagella are highly conserved eukaryotic microtubule-based organelles that
protrude from the surface of most mammalian cells. These structures require large protein …

The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its
environment. Acquiring these functions required the compartmentalization of a dynein …

Hematologic malignancies represent the fourth most frequently diagnosed cancer in
economically developed countries. In hematologic malignancies normal hematopoiesis is …

The mechanisms linking systems-level programs of gene expression to discrete cell
biological processes in vivo remain poorly understood. In this study, we have defined such a …

Cilia are eukaryotic organelles essential for movement, signaling or sensing. Primary cilia
act as antennae to sense a cell's environment and are involved in a wide range of signaling …

Background Dendrites often display remarkably complex and diverse morphologies that are
influenced by developmental and environmental cues. Neuroplasticity in response to …