Polyunsaturated fatty acids (PUFAs) are important components of the diet of mammals. Their
role was first established when the essential fatty acids (EFAs) linoleic acid and α-linolenic …

Leukotrienes are powerful immune-regulating lipid mediators with established pathogenic
roles in inflammatory allergic diseases of the respiratory tract—in particular, asthma and hay …

Diagnosis early in life, sensitization, asthma endotypes, monitoring of disease and treatment
progression are key motivations for the exploration of biomarkers for allergic rhinitis and …

Arachidonic acid (AA) is the precursor to leukotrienes (LT), potent mediators of the
inflammatory response. In the 35+ years since cysteinyl-LTs were reported to mediate …

Leukotrienes are potent immune-regulating lipid mediators with patho-genic roles in
inflammatory and allergic diseases, particularly asthma. These autacoids also contribute to …

Many potentially toxic electrophilic xenobiotics and some endogenous compounds are
detoxified by conversion to the corresponding glutathione S-conjugate, which is metabolized …

Tumor-derived exosomes can modulate the cancer microenvironment and induce metastatic
spread. Exosomes may carry enzymes for leukotriene (LT) biosynthesis, but the role of …

ABSTRACT Introduction: Leukotrienes (LTs) are lipid mediators produced from arachidonic
acid with a broad variety of bioactivities in allergy and inflammation. The biosynthesis of LTs …

The pro-inflammatory leukotrienes (LTs) are formed from arachidonic acid (AA) in activated
leukocytes, where 5-lipoxygenase (5-LO) translocates to the nuclear envelope to assemble …

Resolution of inflammation is an active process regulated by specialized proresolving
mediators where we identified 3 new pathways producing allylic epoxide–derived mediators …