The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …

JF Gudernatsch, an anatomist at Cornell Medical School, traveled by ship to the Naples
Zoological Station in the summer of 1910. He took along various mammalian organs …

Life history theory seeks to explain the evolution of the major features of life cycles by
analyzing the ecological factors that shape age-specific schedules of growth, reproduction …

Metamorphosis, classically defined as a spectacular post-embryonic transition, is well
exemplified by the transformation of a tadpole into a frog. It implies the appearance of new …

As is typical of other hormone systems, the actions of the thyroid hormones (TH) differ from
tissue to tissue depending upon a number of variables. In addition to varying expression …

The current review focuses on the molecular mechanisms and developmental roles of
thyroid hormone receptors (TRs) in gene regulation and metamorphosis in Xenopus laevis …

Publisher Summary Amphibians exhibit considerable diversity in behavioral, physiological,
and life history strategies. They are geographically widespread, occupying a diverse range …

Thyroid hormone system disruption (THSD) negatively affects multiple developmental
processes and organs. In fish, inhibition of deiodinases, which are enzymes crucial for (in) …

Thyroid hormone induces the complete metamorphosis of anuran tadpoles into juvenile
frogs. Arguably, anuran metamorphosis is the most dramatic effect of a hormone in any …

The essential roles of thyroid hormone (TH) in perinatal brain development have been
known for decades. More recently, many of the molecular mechanisms underlying the …