In the past, endothelium was thought to be only a mechanical barrier. Today, endothelium is
known to be a tissue regulating vascular tone, cell growth and the interaction between the …

Diabetes mellitus, a metabolic disease mainly characterized by hyperglycemia, is becoming
a serious social health problem worldwide with growing prevalence. Many natural …

Salt has been linked very closely to the occurrence and complications of arterial
hypertension. A large percentage of patients with essential hypertension are salt‐sensitive; …

It is becoming increasingly apparent that disorders of the brain microvasculature contribute
to many neurological disorders. In recent years it has become clear that a major player in …

Noradrenergic locus coeruleus (LC) neuron loss is a significant feature of mild cognitive
impairment and Alzheimer's disease (AD). The LC is the primary source of norepinephrine in …

Vascular dysfunction is known to be an initiator of the development and progression of
cardiovascular diseases (CVDs). However, there is paucity of information on the relationship …

Heart failure (HF), being a complex pathology that derives from several different conditions
such as idiopathic cardiomyopathy, myocardial infarction (MI), inflammatory diseases …

Atrial fibrillation, a prevalent type of arrhythmia, is increasingly contributing to the economic
burden on healthcare systems. The development of innovative treatments, notably catheter …

Abstract c-Jun N-terminal kinases (JNKs) are involved in the myocardial and aortic
remodeling, increased arterial tone, and arterial blood pressure elevation associated with …

It is becoming increasingly clear that both microvascular network alterations and subsequent
tissue perfusion defects may precede and predict the development of arterial hypertension …