Alzheimer's disease is a rather complex neurodegenerative disease, which is attributed to a
combination of multiple factors. Among the many pathological pathways, synaptic …

There is emerging evidence that diet has a major modulatory influence on brain-gut-
microbiome (BGM) interactions with important implications for brain health, and for several …

Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …

The locus coeruleus (LC), or 'blue spot', is a small nucleus located deep in the brainstem
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This …

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

This review aims to synthesise a large pre-clinical and clinical literature related to a
hypothesised role of the locus coeruleus norepinephrine system in responses to acute and …

Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction,
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …