The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …

T-type calcium channels regulate neuronal excitability and are important contributors of pain
processing. CaV3. 2 channels are the major isoform expressed in nonpeptidergic and …

Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with
diabetes. The mechanisms mediating DNP are not completely elucidated, and effective …

Highlights•Neuropathic pain is a chronic condition that represents a major health
problem.•There is a need for new medications with greater efficacy and less adverse …

Neuropathic pain arises from injury to the nervous system. Conditions associated with
neuropathic pain are diverse, and lesions and/or pathological changes in the central …

Diabetic peripheral neuropathy (DPN) is caused by several factors, including reactive free
oxygen radicals (ROS)-induced excessive Ca2+ influx. Transient receptor potential (TRP) …

Accumulating evidence has demonstrated that epigenetic modification-mediated changes in
pain-related gene expressions play an important role in the development and maintenance …

Diabetic neuropathy (DN) is a common and serious diabetes‐associated complication that
primarily takes place because of neuronal dysfunction in patients with diabetes. Use of …

Decreased AMPK-eNOS bioavailability mediates the development of diabetic peripheral
neuropathy (DPN) through increased apoptosis and decreased autophagy activity in relation …

Pain-sensing sensory neurons (nociceptors) of the dorsal root ganglion (DRG) can become
sensitized (hyperexcitable) in response to pathological conditions such as diabetes, which …