Quorum sensing: a prospective therapeutic target for bacterial diseases

Q Jiang, J Chen, C Yang, Y Yin… - BioMed Research …, 2019 - Wiley Online Library
Bacterial quorum sensing (QS) is a cell‐to‐cell communication in which specific signals are
activated to coordinate pathogenic behaviors and help bacteria acclimatize to the …

Bacterial quorum sensing: its role in virulence and possibilities for its control

ST Rutherford, BL Bassler - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Quorum sensing is a process of cell–cell communication that allows bacteria to share
information about cell density and adjust gene expression accordingly. This process …

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation

CT O'Loughlin, LC Miller, A Siryaporn… - Proceedings of the …, 2013 - National Acad Sciences
Quorum sensing is a chemical communication process that bacteria use to regulate
collective behaviors. Disabling quorum-sensing circuits with small molecules has been …

Exploiting quorum sensing to confuse bacterial pathogens

B LaSarre, MJ Federle - Microbiology and molecular biology …, 2013 - Am Soc Microbiol
Cell-cell communication, or quorum sensing, is a widespread phenomenon in bacteria that
is used to coordinate gene expression among local populations. Its use by bacterial …

Quorum sensing inhibitors as anti-biofilm agents

G Brackman, T Coenye - Current pharmaceutical design, 2015 - ingentaconnect.com
Biofilms are microbial sessile communities characterized by cells that are attached to a
substratum or interface or to each other, are embedded in a self-produced matrix of …

An overview of biofilm formation–combating strategies and mechanisms of action of antibiofilm agents

ST Asma, K Imre, A Morar, V Herman, U Acaroz… - Life, 2022 - mdpi.com
Biofilm formation on surfaces via microbial colonization causes infections and has become a
major health issue globally. The biofilm lifestyle provides resistance to environmental …

Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

O Ciofu, T Tolker-Nielsen, PØ Jensen, H Wang… - Advanced drug delivery …, 2015 - Elsevier
Lung infection is the main cause of morbidity and mortality in patients with cystic fibrosis and
is mainly dominated by Pseudomonas aeruginosa. The biofilm mode of growth makes …

Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways

WRJD Galloway, JT Hodgkinson, SD Bowden… - Chemical …, 2011 - ACS Publications
Numerous species of bacteria employ a mechanism of intercellular communication known
as quorum sensing. This signaling process allows the cells comprising a bacterial colony to …

Combating multidrug‐resistant bacteria: current strategies for the discovery of novel antibacterials

KMG O'Connell, JT Hodgkinson… - Angewandte Chemie …, 2013 - Wiley Online Library
The introduction of effective antibacterial therapies for infectious diseases in the mid‐20th
century completely revolutionized clinical practices and helped to facilitate the development …

Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

S Wagner, R Sommer, S Hinsberger, C Lu… - Journal of medicinal …, 2016 - ACS Publications
Infections with Pseudomonas aeruginosa have become a concerning threat in hospital-
acquired infections and for cystic fibrosis patients. The major problem leading to high …