Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …

Metabolites of glycolytic metabolism have been identified as signaling molecules and
regulators of gene expression, in addition to their basic function as major energy and …

Photodynamic therapy is an alternative treatment mainly for cancer but also for bacterial
infections. This treatment dates back to 1900 when a German medical school graduate …

Strategies to manipulate immune cell co-inhibitory or co-activating signals have
revolutionized immunotherapy. However, certain immunologically cold diseases, such as …

Standard doses of antibiotics do not efficiently treat chronic infections of the soft tissue and
bone. In this Personal View, we advocate for improving treatment of these infections by …

Human epithelia are constantly exposed to microorganisms present in the environment or
residing as part of commensal flora. Despite this exposure, infections involving the skin and …

Bacterial infectious diseases are one of the leading causes of death worldwide. Even with
the use of multiple antibiotic treatment strategies, 4.95 million people died from drug …

Staphylococcus aureus is a prominent human pathogen that readily adapts to host immune
defenses. Here, we show that, in contrast to Gram-negative pathogens, S. aureus induces a …

The innate immune response is a rapid response to pathogens or danger signals. It is
precisely activated not only to efficiently eliminate pathogens but also to avoid excessive …

Due to repeated microbial infection, persistent inflammation, excessive oxidative stress, and
cell dysfunction, chronic wounds are difficult to heal, posing a serious threat to public health …