Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs).
GPCRs act on inactive Gα· GDP/Gβγ heterotrimers to promote GDP release and GTP …

Regulators of G protein signaling (RGS) and RGS-like proteins are a family (> 30 members)
of highly diverse, multifunctional signaling proteins that bind directly to activated Gα …

The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-
hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane …

During asymmetric cell divisions, mitotic spindles align along the axis of polarization. In
invertebrates, spindle positioning requires Pins or related proteins and a G protein α subunit …

Asymmetric divisions are crucial for generating cell diversity; they rely on coupling between
polarity cues and spindle positioning, but how this coupling is achieved is poorly …

Motions related to protein–protein binding events can be surveyed from the perspective of
the Database of Macromolecular Movements. There are a number of alternative conceptual …

Background: Spindle positioning during an asymmetric cell division is of fundamental
importance to ensure correct size of daughter cells and segregation of determinants. In the …

The Caenorhabditis elegans coiled-coil protein LIN-5 mediates several processes in cell
division that depend on spindle forces, including alignment and segregation of …

Heterotrimeric G-proteins bind to cell-surface receptors and are integral in transmission of
signals from outside the cell. Upon activation of the Gα subunit by binding of GTP, the Gα …

▪ Abstract The GoLoco motif is a 19-amino-acid sequence with guanine nucleotide
dissociation inhibitor activity against G-alpha subunits of the adenylyl-cyclase-inhibitory …