Microglia are the only immune cells that permanently reside in the central nervous system
(CNS) alongside neurons and other types of glial cells. The past decade has witnessed a …

Maturation of neuronal circuits requires selective elimination of synaptic connections.
Although neuron-intrinsic mechanisms are important in this process, it is increasingly …

Microglia are the resident immune cells and phagocytes of our central nervous system
(CNS). While most work has focused on the rapid and robust responses of microglia during …

The human brain contains more than 100 trillion (1014) synaptic connections, which form all
of its neural circuits. Neuroscientists have long been interested in how this complex synaptic …

Molecular genetic approaches in small model organisms like Drosophila have helped to
elucidate fundamental principles of neuronal cell biology. Much less is understood about …

Microglia are the predominant immune response cells and professional phagocytes of the
central nervous system (CNS) that have been shown to be important for brain development …

The assembly of functional neural circuits requires the combined action of progressive and
regressive events. Regressive events encompass a variety of inhibitory developmental …

Phagocytosis, a critical early event in the microbicidal response of neutrophils, is now
appreciated to serve multiple functions in a variety of cell types. Professional phagocytes …

The selective elimination of axons, dendrites, axon and dendrite branches, and synapses,
without loss of the parent neurons, occurs during normal development of the nervous system …

Understanding the principles of information processing in neural circuits requires systematic
characterization of the participating cell types and their connections, and the ability to …