Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM)
macromolecules filled with a collection of cells including cancer-associated fibroblasts …

In response to myocardial infarction (MI), cardiac macrophages regulate inflammation and
scar formation. We hypothesized that macrophages undergo polarization state changes over …

ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

Integrins are adhesion receptors that allow cells to sense and respond to
microenvironmental signals encoded by the extracellular matrix. They are crucial for the …

The collagen family of extracellular matrix proteins has played a fundamental role in the
evolution of multicellular animals. At the present, 28 triple helical proteins have been named …

Cancers are complex ecosystems composed of malignant cells embedded in an intricate
microenvironment made of different non-transformed cell types and extracellular matrix …

Cancer-associated fibroblasts (CAFs) are key actors in modulating the progression of many
solid tumors, such as breast cancer (BC). Herein, we identify an integrin α11/PDGFRβ …

The ultimate goal in the design of biomimetic materials for use in tissue engineering as
permanent or resorbable tissue implants is to generate biocompatible scaffolds with …

Collagen, the most abundant protein in animals, is a key component of extracellular
matrices. Not only do collagens provide essential structural support for connective tissues …