Drug abuse is a major global health and economic problem. However, there are no
pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse …

Recent studies examining the neurobiology of substance abuse have revealed a significant
role of neuroimmune signaling as a mechanism through which drugs of abuse induce …

Stress and substance use disorders remain two of the most highly prevalent psychiatric
conditions and are often comorbid. While individually these conditions have a debilitating …

The emphasis of neuronal alterations and adaptations have long been the main focus of the
studies of the mechanistic underpinnings of drug addiction. Recent studies have begun to …

This paper is the forty-second consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

In opioid use disorder (OUD) patients, a decrease in brain grey matter volume (GMV) has
been reported. It is unclear whether this is the consequence of prolonged exposure to …

Substance abuse is one of the significant problems in social and public health worldwide.
Vast numbers of evidence illustrate that motivational and reinforcing impacts of addictive …

Opioid addiction remains a severe health problem. While substantial insights underlying
opioid addiction have been yielded from neuron-centric studies, the contribution of non …

Pain management after oral surgeries is essential to enhance recovery, reduce negative
outcomes and improve the experience of the patient. Naltrexone (NTX) is a non-selective …

Rationale Cocaine can increase inflammatory neuroimmune markers, including chemokines
and cytokines characteristic of innate inflammatory responding. Prior work indicates that the …