T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome
CA Klebanoff, SS Chandran, BM Baker… - Nature Reviews Drug …, 2023 - nature.com
The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
The present and future of bispecific antibodies for cancer therapy
Bispecific antibodies (bsAbs) enable novel mechanisms of action and/or therapeutic
applications that cannot be achieved using conventional IgG-based antibodies …
applications that cannot be achieved using conventional IgG-based antibodies …
The screening, identification, design and clinical application of tumor-specific neoantigens for TCR-T cells
J Li, Z Xiao, D Wang, L Jia, S Nie, X Zeng, W Hu - Molecular Cancer, 2023 - Springer
Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …
Challenges and solutions for therapeutic TCR‐based agents
Recent development of methods to discover and engineer therapeutic T‐cell receptors
(TCRs) or antibody mimics of TCRs, and to understand their immunology and …
(TCRs) or antibody mimics of TCRs, and to understand their immunology and …
Structural basis for T cell recognition of cancer neoantigens and implications for predicting neoepitope immunogenicity
Adoptive cell therapy (ACT) with tumor-specific T cells has been shown to mediate durable
cancer regression. Tumor-specific T cells are also the basis of other therapies, notably …
cancer regression. Tumor-specific T cells are also the basis of other therapies, notably …
Focusing on CD8+ T-cell phenotypes: improving solid tumor therapy
Z Yao, Y Zeng, C Liu, H Jin, H Wang, Y Zhang… - Journal of Experimental …, 2024 - Springer
Vigorous CD8+ T cells play a crucial role in recognizing tumor cells and combating solid
tumors. How T cells efficiently recognize and target tumor antigens, and how they maintain …
tumors. How T cells efficiently recognize and target tumor antigens, and how they maintain …
CrossDome: an interactive R package to predict cross-reactivity risk using immunopeptidomics databases
AF Fonseca, DA Antunes - Frontiers in Immunology, 2023 - frontiersin.org
T-cell-based immunotherapies hold tremendous potential in the fight against cancer, thanks
to their capacity to specifically targeting diseased cells. Nevertheless, this potential has been …
to their capacity to specifically targeting diseased cells. Nevertheless, this potential has been …
Engineering T-cell receptor–like antibodies for biologics and cell therapy
LS Høydahl, G Berntzen, GÅ Løset - Current Opinion in Biotechnology, 2024 - Elsevier
Highlights•Immunotherapy targeting pHLA has entered the clinical stage.•pHLA targets
significantly expands ability to treat diseases with unmet need.•TCR-like antibodies are a …
significantly expands ability to treat diseases with unmet need.•TCR-like antibodies are a …
Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion
Peptide-centric chimeric antigen receptors (PC-CARs) recognize oncoprotein epitopes
displayed by cell-surface human leukocyte antigens (HLAs) and offer a promising strategy …
displayed by cell-surface human leukocyte antigens (HLAs) and offer a promising strategy …
[HTML][HTML] Strengths and limitations of web servers for the modeling of TCRpMHC complexes
Cellular immunity relies on the ability of a T-cell receptor (TCR) to recognize a peptide (p)
presented by a class I major histocompatibility complex (MHC) receptor on the surface of a …
presented by a class I major histocompatibility complex (MHC) receptor on the surface of a …