Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK
cells is their ability to recognize a wide range of cells in distress, particularly tumour cells …

Immune cell engagers are engineered antibodies with at least one arm binding a tumor-
associated antigen and at least another one directed against an activating receptor in …

Natural killer (NK) cell therapies have emerged as a potential therapeutic approach to
various cancers. Their efficacy, however, is limited by their low persistence and anergy …

Simple Summary Innate immune natural killer (NK) cells are capable of killing metastatic
cancer cells without activation by antigen-presenting cells beforehand. The cytotoxic effects …

Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-
infected cells and tumor cells. They are particularly powerful for elimination of hematological …

There have been major advances in the immunotherapy of cancer in recent years, including
the development of T cell engagers—antibodies engineered to redirect T cells to recognize …

The ability of vertebrates to 'remember'previous infections had once been attributed
exclusively to adaptive immunity. We now appreciate that innate lymphocytes also possess …

Novel chimeric antigen receptor (CAR) T-cell approaches are needed to improve
therapeutic efficacy in solid tumors. High-risk neuroblastoma is an aggressive pediatric solid …

NK cells offer a promising alternative to T cell therapies in cancer. We evaluated IPH6501, a
clinical-stage, tetraspecific NK cell engager (NKCE) armed with a non-alpha IL-2 variant (IL …

Natural killer (NK) cells are innate immune effectors whose functions rely on receptors
binding cytokines, recognizing self‐molecules, or detecting danger signals expressed by …