Diabetes is one of the most frequent diseases throughout the world and its incidence is
predicted to exponentially progress in the future. This metabolic disorder is associated with …

The reactive dicarbonyl metabolite methylglyoxal (MG) is the precursor of the major
quantitative advanced glycation endproducts (AGEs) in physiological systems-arginine …

Cellular proteins continuously undergo non-enzymatic covalent modifications (NECMs) that
accumulate under normal physiological conditions and are stimulated by changes in the …

Cancer is a complex disease with a 5–10% hereditary base, but nutrition, lifestyle, and the
environment we are exposed to influence 90–95% of cancers. Due to rapid westernization …

Metabolic reprogramming toward aerobic glycolysis unavoidably induces methylglyoxal
(MG) formation in cancer cells. MG mediates the glycation of proteins to form advanced …

In recent years, glycative stress from exogenous or endogenous advanced glycation end
products (AGEs) and highly reactive dicarbonyls has gained great attention for its putative …

Non-enzymatic posttranslational modifications are believed to affect at least 30% of human
proteins, commonly termed glycation. Many of these modifications are implicated in various …

Simple Summary Diabetic people have an increased risk of developing several types of
cancers, particularly pancreatic cancer. The higher availability of glucose and/or lipids that …

Abstract Small Heat Shock Proteins (sHSPs) evolved early in the history of life; they are
present in archaea, bacteria, and eukaryota. sHSPs belong to the superfamily of molecular …

Protein glycation in biological systems occurs predominantly on lysine, arginine and N-
terminal residues of proteins. Major quantitative glycation adducts are found at mean extents …