The intriguing ligand-dependent and ligand-independent actions of the growth hormone secretagogue receptor on reward-related behaviors

MP Cornejo, ER Mustafá, F Barrile, D Cassano… - Neuroscience & …, 2021 - Elsevier
The growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor
(GPCR) highly expressed in the brain, and also in some peripheral tissues. GHSR activity is …

Metabolic hormones mediate cognition

OR Ghosh-Swaby, AC Reichelt, PAS Sheppard… - Frontiers in …, 2022 - Elsevier
Recent biochemical and behavioural evidence indicates that metabolic hormones not only
regulate energy intake and nutrient content, but also modulate plasticity and cognition in the …

[HTML][HTML] LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue

K Shankar, NP Metzger, O Singh, BK Mani… - Molecular …, 2021 - Elsevier
Objective The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …

Ghrelin-mediated hippocampal neurogenesis: implications for health and disease

L Buntwal, M Sassi, AH Morgan, ZB Andrews… - Trends in Endocrinology …, 2019 - cell.com
There is a close relationship between cognition and nutritional status, however, the
mechanisms underlying this relationship require elucidation. The stomach hormone, ghrelin …

[HTML][HTML] Neuronal ablation of GHSR mitigates diet-induced depression and memory impairment via AMPK-autophagy signaling-mediated inflammation

H Wang, Z Shen, CS Wu, P Ji, JY Noh… - Frontiers in …, 2024 - frontiersin.org
Obesity is associated with chronic inflammation in the central nervous system (CNS), and
neuroinflammation has been shown to have detrimental effects on mood and cognition. The …

Ghrelin in Alzheimer's disease: pathologic roles and therapeutic implications

SG Jeon, SB Hong, Y Nam, J Tae, A Yoo… - Ageing Research …, 2019 - Elsevier
Ghrelin, which has many important physiological roles, such as stimulating food intake,
regulating energy homeostasis, and releasing insulin, has recently been studied for its roles …

Appetite to learn: An allostatic role for AgRP neurons in the maintenance of energy balance

F Reed, SH Lockie, A Reichenbach, CJ Foldi… - Current Opinion in …, 2022 - Elsevier
The relationship between hunger and subsequent feeding has undoubtedly provided strong
selective pressures that underpin motivation, learning and memory processes. Together …

Ghrelin mediated hippocampal neurogenesis

JS Davies - Vitamins and Hormones, 2022 - Elsevier
The stomach hormone, ghrelin, which is released during food restriction, provides a link
between circulating energy state and adaptive brain function. The maintenance of such …

Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats

JA Herrington, J Guss Darwich… - Developmental …, 2022 - Wiley Online Library
A growing body of evidence links prenatal and early postnatal acetaminophen (APAP)
exposure to atypical development of brain and behavior. In adult rodents, APAP is known to …

Ghrelin-mediated regeneration and plasticity after nervous system injury

I Stoyanova, D Lutz - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
The nervous system is highly vulnerable to different factors which may cause injury followed
by an acute or chronic neurodegeneration. Injury involves a loss of extracellular matrix …