New insights into the circadian rhythm and its related diseases

Y Xie, Q Tang, G Chen, M Xie, S Yu, J Zhao… - Frontiers in …, 2019 - frontiersin.org
Circadian rhythms (CR) are a series of endogenous autonomous oscillators generated by
the molecular circadian clock which acting on coordinating internal time with the external …

Circadian regulation of macrophages and osteoclasts in rheumatoid arthritis

N Kikyo - International journal of molecular sciences, 2023 - mdpi.com
Rheumatoid arthritis (RA) represents one of the best examples of circadian fluctuations in
disease severity. Patients with RA experience stiffness, pain, and swelling in afflicted joints …

Circadian rhythms affect bone reconstruction by regulating bone energy metabolism

B Luo, X Zhou, Q Tang, Y Yin, G Feng, S Li… - Journal of Translational …, 2021 - Springer
Metabolism is one of the most complex cellular biochemical reactions, providing energy and
substances for basic activities such as cell growth and proliferation. Early studies have …

Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1

J Peng, J Zhao, Q Tang, J Wang, W Song… - International Journal of …, 2022 - nature.com
Bone regeneration remains a great clinical challenge. Low intensity near-infrared (NIR) light
showed strong potential to promote tissue regeneration, offering a promising strategy for …

The biological function of BMAL1 in skeleton development and disorders

G Chen, Q Tang, S Yu, Y Xie, J Sun, S Li, L Chen - Life Sciences, 2020 - Elsevier
BMAL1 is a core component of the circadian clock loop, which directs the sophisticated
circadian expression of clock-controlled genes. Skeletal Bone development is a complex …

Circadian clock—A promising scientific target in oral science

G Feng, J Zhao, J Peng, B Luo, J Zhang… - Frontiers in …, 2022 - frontiersin.org
The oral and maxillofacial organs play vital roles in chewing, maintaining facial beauty, and
speaking. Almost all physiological processes display circadian rhythms that are driven by …

[HTML][HTML] Circadian clock genes as promising therapeutic targets for bone loss

Y Qin, Z Chen, JJ Wu, ZY Zhang, ZD Yuan… - Biomedicine & …, 2023 - Elsevier
The circadian clock regulates many key physiological processes such as the sleep–wake
cycle, hormone release, cardiovascular health, glucose metabolism and body temperature …

CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced Osteoporosis via Modulating RANKL and ROS Signaling Pathways

J Li, J Liang, L Wu, Y Xu, C Xiao, X Yang… - Frontiers in …, 2022 - frontiersin.org
Osteoclasts are of hematopoietic lineage and have the ability to degrade mineralized bone
tissues. Abnormalities in osteoclastic activity under certain pathological conditions are …

Accuracy of virtually planned mandibular distraction in a pediatric case series

V Vanesa, MP Irene, AS Marta, PFF José… - Journal of Cranio …, 2021 - Elsevier
The aim of this study was to describe the utility of 3D technology in mandibular distraction
(MD) for patients with mandibular hypoplasia (MH), using 3D-printed cutting guides (CGs) …

[HTML][HTML] BMAL1 deficiency provokes dry mouth and eyes by down-regulating ITPR2/3

X Zhang, G Chen, Y He, Q Tang, Y Yin, Y Jie - The Ocular Surface, 2024 - Elsevier
Secretory glands, responsible for tears and saliva production, play essential roles in
maintaining ocular and oral well-being. Disruptions in gland secretion can arise from various …