Characterization of the SARS-CoV-2 genome 3′-untranslated region interactions with Host MicroRNAs
CJ Frye, CL Cunningham, MR Mihailescu - ACS omega, 2024 - ACS Publications
The 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), has marked the spread of a novel human coronavirus. SARS-CoV-2 has exhibited …
CoV-2), has marked the spread of a novel human coronavirus. SARS-CoV-2 has exhibited …
Effect of the SARS-CoV-2 Delta-associated G15U mutation on the s2m element dimerization and its interactions with miR-1307-3p
The s2m, a highly conserved 41-nt hairpin structure in the SARS-CoV-2 genome, serves as
an attractive therapeutic target that may have important roles in the virus life cycle or …
an attractive therapeutic target that may have important roles in the virus life cycle or …
NMR characterization and ligand binding site of the stem–loop 2 motif from the Delta variant of SARS-CoV-2
T Matzel, MW Martin, A Herr, A Wacker, C Richter… - RNA, 2024 - rnajournal.cshlp.org
The stem–loop 2 motif (s2m) in SARS-CoV-2 (SCoV-2) is located in the 3′-UTR. Although
s2m has been reported to display characteristics of a mobile genomic element that might …
s2m has been reported to display characteristics of a mobile genomic element that might …
Delta SARS-CoV-2 s2m structure, dynamics, and entropy: consequences of the G15U mutation
JA Makowski, AH Kensinger… - ACS Physical …, 2023 - ACS Publications
Bioinformatic analysis of the Delta SARS-CoV-2 genome reveals a single nucleotide
mutation (G15U) in the stem-loop II motif (s2m) relative to ancestral SARS-CoV-2. Despite …
mutation (G15U) in the stem-loop II motif (s2m) relative to ancestral SARS-CoV-2. Despite …
[HTML][HTML] Host microRNA interactions with the SARS-CoV-2 viral genome 3'-untranslated region
CJ Frye, CL Cunningham, MR Mihailescu - bioRxiv, 2023 - ncbi.nlm.nih.gov
The 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), has marked the spread of a novel human coronavirus. While the viral life cycle is …
CoV-2), has marked the spread of a novel human coronavirus. While the viral life cycle is …
4-Aminoquinolines modulate RNA structure and function: Pharmacophore implications of a conformationally restricted polyamine
MI Hossain, M Myers, D Herath, AH Aldhumani… - Biochemical and …, 2023 - Elsevier
RNA structure plays an important role in regulating cellular function and there is a significant
emerging interest in targeting RNA for drug discovery. Here we report the identification of 4 …
emerging interest in targeting RNA for drug discovery. Here we report the identification of 4 …
Interactions of the SARS-CoV-2 Viral Genome 3'-Untranslated Region with Viral and Host RNAs
CJ Frye - 2024 - search.proquest.com
This dissertation focuses on the characterization of RNA-RNA interactions within the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome and with host microRNAs …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome and with host microRNAs …