Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

The kidneys are frequently targeted by pathogenic immune responses against renal
autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent …

The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

The glomerulus is a highly specialized capillary tuft, which under pressure filters large
amounts of water and small solutes into the urinary space, while retaining albumin and large …

Macrophages tailor their function according to the signals found in tissue
microenvironments, assuming a wide spectrum of phenotypes. A detailed understanding of …

Progressive loss of podocytes is the most frequent cause accounting for end-stage renal
failure. Podocytes are complex, terminally differentiated cells incapable of replicating. Thus …

Th17 cells are most abundant in the gut, where their presence depends on the intestinal
microbiota. Here, we examined whether intestinal Th17 cells contribute to extra-intestinal …

Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive
fibrosis, ultimately leading to end‐stage renal disease. Although many studies have …

Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus
emphasizing the need to better understand the molecular mechanisms of damage and …

Chronic kidney disease (CKD) is a major health and economic burden with a rising
incidence. During progression of CKD, the sustained release of proinflammatory and …