DNA glycosylases safeguard the genome by locating and excising a diverse array of
aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the …

Nitric oxide (NO•) is generated by the innate immune response to neutralize pathogens. NO•
and its autoxidation products have an extensive biochemical reaction network that includes …

3-Methyladenine DNA glycosylase II (AlkA) is an enzyme that cleaves a wide range of
damaged bases from DNA. The gas-phase thermochemical properties (tautomerism, acidity …

Rad4/XPC recognizes diverse DNA lesions to initiate nucleotide excision repair (NER).
However, NER propensities among lesions vary widely and repair-resistant lesions are …

Hydrolysis of the N-glycosyl bond between a nucleobase and deoxyribose leaves an abasic
site within duplex DNA. The abasic site can react with exocyclic amines of nucleobases on …

The hyperthermophilic and radioresistant euryarchaeon Thermococcus gammatolerans
encodes a putative 3-methlyadenine DNA glycosylase II (Tg-AlkA). Herein, we report …

Aag from Bacillus subtilis has been implicated in in vitro removal of hypoxanthine and
alkylated bases from DNA. The regulation of expression of aag in B. subtilis and the …

Escherichia coli 3-methyladenine DNA glycosylase II (AlkA), an adaptive response
glycosylase with a broad substrate range, initiates base excision repair by flipping a lesion …

The adenine, cytosine, and guanine bases of DNA are susceptible to alkylation by the
aldehyde products of lipid peroxidation and by the metabolic byproducts of vinyl chloride …

After the hydrolysis of the N-glycosyl bond between a damaged base and C1′ of a
deoxyribosyl moiety of DNA, human alkyladenine DNA glycosylase (AAG) and Escherichia …