Poly (A) tails have long been known as stable 3′ modifications of eukaryotic mRNAs,
added during nuclear pre‐mRNA processing. It is now appreciated that this modification is …

The transparency of Caenorhabditis elegans provides a unique window to observe and
study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) …

The nematode Caenorhabditis elegans is an important model for studies of germ cell
biology, including the meiotic cell cycle, gamete specification as sperm or oocyte, and …

Poly (A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called
cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has …

Translational control of mRNAs in dendrites is essential for certain forms of synaptic
plasticity and learning and memory. CPEB is an RNA-binding protein that regulates local …

RNA binding proteins (RBPs) are key players in the regulation of gene expression. In this
chapter we discuss the main protein–RNA recognition modes used by RBPs in order to …

Cytoplasmic polyadenylation is the process by which dormant, translationally inactive
mRNAs become activated via the elongation of their poly (A) tails in the cytoplasm. This …

The addition of a poly (A)-tail to the 3′ termini of RNA molecules influences stability,
nuclear export, and efficiency of translation. In the cytoplasm, dynamic changes in the length …

Cytoplasmic polyadenylation plays a vital role in gametogenesis; however, the participating
enzymes and substrates in mammals remain unclear. Using knockout and knock-in mouse …

Stem cells are essential for tissue generation during the development of multicellular
creatures, and for tissue homeostasis in adults. The great therapeutic promise of stem cells …