Endocytosis and transcytosis of SARS-CoV-2 across the intestinal epithelium and other tissue barriers

E Knyazev, S Nersisyan, A Tonevitsky - Frontiers in immunology, 2021 - frontiersin.org
Since 2003, the world has been confronted with three new betacoronaviruses that cause
human respiratory infections: SARS-CoV, which causes severe acute respiratory syndrome …

The envelope (E) protein of SARS-coV-2 as a pharmacological target

T Santos-Mendoza - Viruses, 2023 - mdpi.com
The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern.
Several spike (S) protein-based vaccines have been developed that efficiently protect the …

Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1

J Chai, Y Cai, C Pang, L Wang, S McSweeney… - Nature …, 2021 - nature.com
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has created global health and
economic emergencies. SARS-CoV-2 viruses promote their own spread and virulence by …

Host PDZ‐containing proteins targeted by SARS‐CoV‐2

C Caillet‐Saguy, F Durbesson, VV Rezelj… - The FEBS …, 2021 - Wiley Online Library
Small linear motifs targeting protein interacting domains called PSD‐95/Dlg/ZO‐1 (PDZ)
have been identified at the C terminus of the severe acute respiratory syndrome coronavirus …

Comparing the binding properties of peptides mimicking the Envelope protein of SARS‐CoV and SARS‐CoV‐2 to the PDZ domain of the tight junction‐associated …

A Toto, S Ma, F Malagrinò, L Visconti, L Pagano… - Protein …, 2020 - Wiley Online Library
The Envelope protein (E) is one of the four structural proteins encoded by the genome of
SARS‐CoV and SARS‐CoV‐2 Coronaviruses. It is an integral membrane protein, highly …

[HTML][HTML] Specificity in PDZ-peptide interaction networks: Computational analysis and review

JF Amacher, L Brooks 3rd, TH Hampton… - Journal of Structural …, 2020 - Elsevier
Globular PDZ domains typically serve as protein–protein interaction modules that regulate a
wide variety of cellular functions via recognition of short linear motifs (SLiMs). Often, PDZ …

Functional pangenome analysis shows key features of E protein are preserved in SARS and SARS-CoV-2

I Alam, AA Kamau, M Kulmanov, Ł Jaremko… - Frontiers in cellular …, 2020 - frontiersin.org
The spread of the novel coronavirus (SARS-CoV-2) has triggered a global emergency, that
demands urgent solutions for detection and therapy to prevent escalating health, social, and …

What do we know about the function of SARS-CoV-2 proteins?

S Justo Arevalo, A Castillo-Chávez… - Frontiers in …, 2023 - frontiersin.org
The COVID-19 pandemic has highlighted the importance in the understanding of the biology
of SARS-CoV-2. After more than two years since the first report of COVID-19, it remains …

Viral subversion of the cell polarity regulator Scribble

A Javorsky, PO Humbert… - Biochemical Society …, 2023 - portlandpress.com
Scribble is a scaffolding protein that regulates key events such as cell polarity,
tumorigenesis and neuronal signalling. Scribble belongs to the LAP family which comprise …

[HTML][HTML] Viral manipulation of cell polarity signalling

A Javorsky, PO Humbert, M Kvansakul - Biochimica et Biophysica Acta …, 2023 - Elsevier
Cell polarity refers to the asymmetric distribution of biomacromolecules that enable the
correct orientation of a cell in a particular direction. It is thus an essential component for …