Biological role of Piper nigrum L.(Black pepper): A review

N Ahmad, H Fazal, BH Abbasi, S Farooq, M Ali… - Asian Pacific Journal of …, 2012 - Elsevier
Piper nigrum L. is considered the king of spices throughout the world due to its pungent
principle piperine. Peppercorn of Piper nigrum as a whole or its active components are used …

Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper

S Shityakov, E Bigdelian, AA Hussein… - European journal of …, 2019 - Elsevier
Plants are vital for the wellbeing of humankind in a variety of ways. Some plant extracts
contain antimicrobial properties that can treat different pathogens. Most of the world's …

Piperine as a potential anti-cancer agent: a review on preclinical studies

A Manayi, SM Nabavi, WN Setzer… - Current medicinal …, 2018 - ingentaconnect.com
Recently many studies showed anticancer activities of piperine, a pungent alkaloid found in
black pepper and some other Piper species. We attempted to summarize acquired data that …

Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes: In vivo and in silico studies

M Afroz, MS Bhuia, MA Rahman, R Hasan… - European Journal of …, 2024 - Elsevier
Piperine is a natural alkaloid that possesses a variety of therapeutic properties, including
anti-inflammatory, antioxidant, antibacterial, and anticarcinogenic activities. The present …

New natural pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) and iNOS inhibitors identified from Penicillium polonicum through in vitro and in vivo studies

PP Pal, AS Begum, SA Basha, H Araya… - International …, 2023 - Elsevier
Overexpression of pro-inflammatory cytokines and iNOS have been found to be concomitant
with several chronic inflammatory diseases and hence targeting their inhibition would be a …

Analytical method development and validation of reverse-phase high-performance liquid chromatography (RP-HPLC) method for simultaneous quantifications of …

VS Chaudhari, RM Borkar, US Murty… - Journal of Pharmaceutical …, 2020 - Elsevier
Quercetin and piperine are often used as an add-on therapy for various diseases, however
both drug exhibits poor aqueous solubility and photosensitivity issue. Therefore, the aim of …

Bioenhancers from mother nature and their applicability in modern medicine

GK Randhawa, JS Kullar - … journal of applied and basic medical …, 2011 - journals.lww.com
Abstract Concept of bioenhancers or biopotentiators was first time reported in 1929 by Bose.
A bioenhancer is an agent capable of enhancing bioavailability and efficacy of a drug with …

[HTML][HTML] A review on diversified use of the king of spices: Piper nigrum (black pepper)

DR Joshi, AC Shrestha, N Adhikari - Int J Pharm Sci Res, 2018; 9 …, 2019 - researchgate.net
Black pepper, the'King of spices'(Piper nigrum L.), is a widely used spice, known for its
pungent odour. From time immemorial, plant sources were used in traditional systems of …

Safety aspects of the use of isolated piperine ingested as a bolus

R Ziegenhagen, K Heimberg, A Lampen… - Foods, 2021 - mdpi.com
Piperine is a natural ingredient of Piper nigrum (black pepper) and some other Piper
species. Compared to the use of pepper for food seasoning, piperine is used in food …

Targeting hepatocellular carcinoma with piperine by radical-mediated mitochondrial pathway of apoptosis: An in vitro and in vivo study

V Gunasekaran, K Elangovan, SN Devaraj - Food and Chemical Toxicology, 2017 - Elsevier
Redox mediated cancer therapeutics are of immense interest in the recent decade due to
their anticancer activity. Piperine is the principal alkaloid of black and long pepper. Although …