Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …

Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …

Cytochromes P450s (CYPs) constitute a superfamily of enzymes that catalyze the
metabolism of drugs and other substances. Endogenous substrates of CYPs include …

In chemical terms, the regio-and stereoselective hydroxylation of hydrocarbon CH bonds is a
very difficult transformation. Nevertheless, these reactions are deftly catalyzed by a variety of …

Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

The introduction of oxygen into biochemical processes has brought about an evolutionary
leap in the history of life, whereby many organisms have evolved to use oxygen as part of …

1.1 Background Dendrimers and dendrons are architectural motifs synthesized by either
divergent or convergent iterative methods, and therefore, they provide monodisperse …

The field of cytochrome P450 (P450) research has developed considerably over the past 20
years, and many important papers on the roles of P450s in chemical toxicology have …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …